The Jiang laboratory in the Department of Neuroscience at Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital is seeking applicants for postdoc associate positions. The specific goal of the postdoc fellows for these positions is to use a multi-disciplinary approach, including single-cell RNA sequencing, Patch-seq, multi-patch clamp recording, machine learning, and complicated genetic tools to understand cellular heterogeneity and circuit organization of healthy and diseased brains. The fellows will use rodent and primate models, including surgically resected human tissue, to understand brain cell types with the molecular, spatial, and morpho-electric annotations, and how genetic lesions (related to epilepsy and autism) give rise to culprit cell types that contribute to the core symptoms of affected individuals. You can learn more about our research at (https://www.bcm.edu/research/labs-and-centers/faculty-labs/xiaolong-jiang-lab) and more specific information for current projects from recent publications in our lab:
Jiang X., Shen S., Cadwell C.R., Berens P., Sinz F., Ecker A.S., Tolias A.S. (2015). Principles of Connectivity among Morphologically Defined Cell Types in Adult Neocortex. Science. Vol. 350 no. 6264 DOI: 10.1126
Cadwell CR, Palasantza A, Jiang X, Berens P, Deng Q, Yilmaz M, Reimer J, Shen S, Bethge M, Tolias KF, Sandberg R & Tolias AS (2016). Morphological, electrophysiological, and transcriptomic profiling of single neurons using Patch-seq. Nature Biotechnology, 34(2), 199-203. doi: 10.1038/nbt.3445. Epub 2015 Dec 21.
Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell CR, Hartmanis H, Castro J, Tan ZH, Sandberg S, Berens P, Jiang X*, Tolias AT*. Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas. Nature Communication. volume 10, Article number: 4174 (2019) *co-corresponding authors
Cadwell C, Scala F, Fahey PG, Kobak D, Mulherkar S, Sinz FH, Papadopoulos S, Tan ZH, Johnsson P, Hartmanis L, Li S, Cotton RJ, Tolias KF, Sandberg R, Berens P, Jiang X*, and Tolias AS*, Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex. Elife, 2020;9:e52951. *co-corresponding authors
1. Using single-nucleus RNA-sequencing, Patch-seq, multi-patching electrophysiology, and other molecular techniques on primate brain tissue to decipher and define cellular constituents of cortical circuits with molecular, morpho-electric, spatial, and functional annotations in the primate brain.
2. Probe and define the cellular constituents of brain circuits associated with epilepsy and autism.
3. Perform rigorous and well-controlled experiments as well as data analysis
4. Summarize research findings, publish results in research journals, and presentation of research
results at professional conferences.
MD or Ph.D. in Basic Science, Health Science, or a related field.
Extensive knowledge of single-cell RNA-seq, bioinformatics analysis, and molecular techniques.
Experience with patch-clamp electrophysiology.
Excellent written/oral communication and organizational skills are required, and work effectively in a team environment.
Tagged as: Life Sciences
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