The Arbely Lab for synthetic biology in the Department of Chemistry, Ben Gurion University, recruits postdoctoral fellows and PhD students to join an exciting study of enzyme regulation by posttranslational modifications. Thousands of lysine acetylation sites were recently discovered on non-histone proteins, suggesting that acetylation is a widespread and evolutionarily conserved posttranslational modification. Specifically, it was found that most of the enzymes of central metabolic processes are acetylated, implying that acetylation is a key regulator of cellular metabolism. The overall aim of our research is to understand the role of lysine acylation in the regulation of metabolic enzymes and how deacetylases regulate specific lysine acylation events. To this end, our lab develops and applies cutting-edge synthetic biology- and chemical biology-based tools for the genetic encoding of posttranslational modifications and activity-based probes in full-length proteins. Research in the lab is interdisciplinary, combining various approaches, including synthetic biology (genetic code expansion technology), enzyme biochemistry, protein chemistry, and synthetic organic chemistry. We welcome applications from candidates with experience and background in one or more of the following fields: biochemistry, synthetic biology, structural biology, metabolomics, synthetic organic chemistry, and cell biology.
We now have several fully-funded postdoc and PhD positions. If you are interested, please send your CV and cover letter to Prof. Eyal Arbely: email@example.com
Tagged as: Chemistry, Life Sciences
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