A postdoctoral research position is available in Dr. Daniel Bolnick’s research group (https://bolnicklab.wordpress.com), in the Department of Ecology and Evolution at the University of Connecticut. The postdoc will join an ongoing NIH-funded project to use CRISPR/cas9 gene editing of threespine stickleback to evaluate the phenotypic effect of candidate genes on host immune phenotypes and resistance to cestode infection. The postdoc may also begin work on a related question of how cestode genotype affects infection outcome.
Tasks: The postdoctoral researcher will combine experimental genetics with immune challenges to identify the genetic and immunological basis of rapidly-evolved population differences in stickleback immunity to a cestode parasite, and associated costly immunopathology. The Bolnick lab has identified naturally evolved heritable differences in stickleback fishes’ ability to resist infection, and suppress growth of established cestodes. This resistance entails a recently-evolved fibrosis immune response that can be experimentally studied using an artificial vaccination strategy (see https://bolnicklab.wordpress.com/2015/10/12/bolnick-lab-publications/ for recent publications concerning evolution of cestode resistance and fibrosis). Using QTL mapping, GWAS, population genomic divergence, and transcriptomics we have identified promising candidate genes potentially underlying these immunological differences. With funding from NIH, we have successfully implemented CRISPR/cas9 gene editing of some candidate genes. The postdoc hired for this position will extend this gene editing work to encompass more replicates, more candidate genes, and evaluate the phenotypic effect of these transgenic manipulations using experimental infections and artificial vaccination assays. The work will be based at the University of Connecticut, though some field work may be necessary, such as to breed fish for lab work or to obtain cestodes. The postdoc will be responsible for conducting lab and field work, co-supervising laboratory technicians and students, data analysis and publication. Opportunities exist to pursue side-projects along with the core project task.
Duration: The position is available for up to two years, subject to annual review of performance. The position could extend longer, contingent on availability of additional grant funds. The postdoc should be able to start in spring or summer of 2021, exact dates to be negotiated with the PI.
Compensation: Starting salary will be $52,850, plus health benefits.
Qualifications: Applicants must have a PhD in evolutionary biology, genetics, immunology, or a closely related field. Prior experience with molecular genetics or immunology is essential (preferably both). Expertise in CRISPR/cas9 gene editing is strongly preferred. Previous research experience and publications should demonstrate a commitment to basic research, good work ethic, lab skills, organizational ability, and publication productivity.
Applications should electronically submit a single pdf file containing the following, in order, via the following website:
1) A statement of past research achievements, including relevant skills (1-2 pages)
2) A statement of what you can contribute to the Bolnick Lab’s research (1 page)
4) A copy of two publications or submitted manuscripts.
3) A list of three references, with contact information (email, telephone, and mailing address). We will request letters directly from these references, after identifying top candidates.
An initial application should be emailed to Dr. Daniel Bolnick ( email@example.com ), though applicants will eventually need to also submit materials via the University of Connecticut job site once the position is posted (URL to be determined, inquire from Dr. Bolnick). Include the subject line “Evolutionary immune genetics Postdoc: <YOUR NAME>”. Application review will begin on November 9, 2020, though late applications will be accepted until December 8.
For questions about this position, please email Dr. Bolnick (firstname.lastname@example.org). For information about the Bolnick Lab visit the lab website (https://bolnicklab.wordpress.com ), lab photostream (https://www.flickr.com/photos/98765823@N08/albums), and Dr. Bolnick’s Google Scholar page (https://scholar.google.com/citations?user=cfwxm0AAAAAJ&hl=en).
The University of Connecticut is an Equal Opportunity Employer. Applicants with questions about disability services can privately discuss their application with the University of Texas Disability Services Office (http://sites.utexas.edu/disability/ ). A statement of BolnickLab values can be found here: https://bolnicklab.wordpress.com/2015/10/01/labvalues/
Tagged as: Life Sciences
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