Postdoctoral positions are available now in the laboratory of Dr. Huiqing (Jane) Zhou, Assistant Professor of Chemistry, starting from September 2020 at Boston College. The Zhou research group focuses on developing and applying new technologies to detect and quantify chemical modifications in the mammalian transcriptome at base-resolution, studying molecular mechanisms of how chemical modifications and their regulatory network function in biology and diseases, and developing tools to modulate transcript-specific RNA modification level in order to revert dysregulated epitranscriptome in diseases. Projects in the Zhou lab take interdisciplinary approaches including directed evolution, protein engineering, RNA and enzyme biochemistry, mass spectrometry, next-generation sequencing, bioinformatics, and structural biology. Ultimately, research in the Zhou lab aims to achieve an in-depth understanding of regulatory mechanisms of epitranscriptome that can lead to discoveries of novel drug targets and to diversify the toolbox of therapeutics targeting the epitranscriptome. For more details, please check out https://sites.bc.edu/huiqing-zhou/.
Dr. Zhou earned her Ph.D. degree at Duke University, under the supervision of Prof. Hashim Al-Hashimi; her Ph.D. thesis reveals the formation of Hoogsteen base-pairing in double-stranded DNA rather than RNA as an intrinsic difference embedded in two types of nucleic acids, shedding light onto why the double helix DNA is selected as the material to carry the genetic information for the majority of life forms (Zhou et al Nat. Struct. Mol. Biol. 2016). Dr. Zhou continued as a joint postdoctoral scholar with Prof. Chuan He and Prof. Bryan Dickinson at the University of Chicago, working on thriving interdisciplinary fields of chemical biology and epitranscriptomics that study how chemically modified RNA play essential roles in fundamental biological processes, development, and diseases. Dr. Zhou led the development of a fluorescence-based directed evolution platform engineering reverse transcriptases that specifically encodes a chemically modified RNA (e.g. N1-methyladenosine) into mutation signatures that can be detected by next-generation sequencing technology. The engineered reverse transcriptase gets further applied into transcriptome-wide, base-resolution mapping of N1-methyladenosine in human messenger RNA (Zhou et al Nat. Methods 2019; commented by Wang Nat. Methods 2019).
Candidates must have, or nearly complete, a Ph.D. or equivalent degree in chemistry, biochemistry, biophysics, cell biology, bioinformatics, or related disciplines. Salary will be commensurate with university guidelines and supported by startup funding. Applicants should send a combined pdf that includes 1) a detailed CV, 2) contact information for at least two references, and 3) a cover letter describing the candidate’s past research summary, future research interests, and academic goal, to email@example.com.
Tagged as: Chemistry, Life Sciences
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