Dr. Wolpaw’s laboratory in the Center for Childhood Cancer Research at the Children’s Hospital of Philadelphia (CHOP) and the Department of Pediatrics at the University of Pennsylvania (UPENN) seeks to develop an understanding of how tumor heterogeneity and epigenetics impact inflammatory signaling and immunotherapy responses in pediatric solid tumors with a goal of developing more efficacious, less toxic therapies to treat these devastating diseases. The laboratory is located in the heart of the CHOP/UPENN campus in West Philadelphia, which provides a vibrant and collaborative community of researchers and clinicians with extensive educational opportunities including lecture series and networking events.
Dr. Wolpaw is seeking a motivated, enthusiastic, and hard-working post-doctoral fellow (Ph.D., M.D., or M.D.-Ph.D) to lead a project focused on using murine models to investigate how neuroblastoma lineage heterogeneity impacts the tumor immune microenvironment, surface protein expression, and response to immunotherapy. This work builds on our recently published study in PNAS (https://www.pnas.org/doi/10.1073/pnas.2102358119) and is fully funded by grants from the Department of Defense and the NIH.
Applicants should have good skills in cancer biology, molecular biology, cell culture, flow cytometry, and basic mouse handling techniques as well as the ability to interface with transcriptomic and epigenomic datasets and the motivation to gain new technical skills. The applicant will be expected to conduct independent scholarly research and will be involved in project planning, performing, and interpreting experiments, and communicating results in the form of scientific meeting presentations and the writing of manuscripts. This job is open to those seeking first or second post-docs.
Tagged as: Life Sciences
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