Research Program Description:
The Lambert lab (http://www.crchudequebec.ulaval.ca/en/research/researchers/jean-philippe-lambert/) is seeking a master student to contribute to on-going quantitative and functional proteomics studies. More specifically, the selected student will actively participate to the deployment and use of novel bioinformatics solution for the analysis of proteomics data from “data dependent acquisition” and “data independent acquisition” experiments performed in the research group.
The proposed research will involve clinical projects in which the proteome of tissues and fluids from human and rodent origin will be characterized to enhance our comprehension of multiple pathologies and cancers. The selected student will also support more fundamental projects in which we are aiming to characterized mode of regulation of transcription and their impacts in numerous cellular contexts. As part of his/her studies, the selected student will be exposed to an array of proteomics, cellular and molecular biology and biochemical techniques routinely employed in the lab to supplement his/her bioinformatics work.
In addition, the selected student will actively contribute to the writing of scientific manuscripts in addition to presenting his/her results in local, national and international conferences.
We are seeking a recent B.Sc. graduate with a very good academic standing in the field of bioinformatic or life sciences (genomics, biochemistry, molecular biology, etc.) who is dynamic and highly motivated by the possibility of doing scientific research.
A demonstrated experience in the use of bioinformatic tools is required.
An advance mastery of the English language, that is a level proficiency sufficient for the fluent reading, writing and talking about science matters, is required.
Experiences in the analysis of proteomics data (for example with the MaxQuant or Skyline tools) or in the use of virtualized servers (e.g. with Proxmox) are assets.
To apply, the candidate must provide a cover letter and a CV (containing recent academic transcripts) to:
Financial support of 18,000$/year for 2 years will be provided.
Please note that only selected applicants will be contacted.
About Dr. Jean-Philippe Lambert
Dr. Lambert is an expert in the use of functional proteomics and mass spectrometry-based techniques. His research program aims to better understand the loss of transcriptional flexibility found in numerous cancer cells and how this change can be targeted for clinical benefit. His group develops and employs novel proteomics and genomics approaches, in additional to an array of molecular, biochemical and imaging techniques, to explore modes of transcriptional regulation and how their deregulation leads to cancer. To do so, he has developed numerous experimental pipelines allowing for the characterization of protein complexes associated with chromatin and deployed them in multiple biological systems. He has also significantly contributed to the integration of Data Independent Acquisition (DIA) approaches in functional proteomics allowing for the detailed quantification of modulated protein-protein interactions. The quality of his work has been recognized through multiple fellowships, a Scholarship for the Next Generation of Scientists from the Cancer Research Society in 2015 and most recently, an Early Career Award in Cancer from the Canadian Institutes of Health Research-Institute of Cancer Research and the inaugural Canadian National Proteomics Network (CNPN) Young Investigator award.
About the CHU de Québec-Université Laval Research Center – CHUL
The Lambert laboratory is located at the CHU de Québec-Université Laval research center – CHUL host of ~500 researcher and ~1000 students. It is part of a thriving biomedical research environment in Quebec City and is equipped with cutting-edge equipment allowing for the analysis of proteins by mass spectrometry in addition to next-generation sequencing and confocal microscopy.
Tagged as: Life Sciences
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