We are offering a PhD position in our Precision Medicine and Metabolism lab led by Dr. Oscar Millet at the CIC bioGUNE research institute in Bilbao, Spain. We are looking for a motivated foreign PhD candidate willing to develop a research project in the emerging topic of the Precision Medicine with special interest in the effect of the protein stability and homeostasis in the metabolism.
Protein stability (thermodynamic and kinetic) drives the biophysical properties of the polypeptide chain (protein folding) and the protein’s concentration in the cellular environment (protein homeostasis). It is the result of a delicate balance between inter- and intramolecular interactions, which can be easily altered by mutations and/or upon changes in the composition of the surrounding media. In this context, NMR spectroscopy offers a plethora of suitable experiments to investigate protein stability. In our laboratory we are currently interested in the following topics:
– Pharmacological chaperones. Rare diseases (~7000 identified to date) are an area of significant medical need affecting an estimated 350 million people worldwide, with ~95% having no currently approved drug treatment. They are often produced by inherited mutations affecting the activity of a protein and It is becoming increasingly clear that, most frequently, a mutation destabilizes the protein/enzyme, ultimately affecting its intracellular homeostasis. In this context, pharmacological chaperones (small molecules which bind to the protein, restoring stability and activity without affecting its function) can be applied to many diseases. In our laboratory we are investigating new methods (NMR, biophysical and biochemical) for the discovery and characterization of pharmacological chaperones against a set of diseases: congenital eryhtropoietic porphyria, tyrosianemia.
– Environmental modulation of enzyme stability. The high catalytic efficiency and the exquisite enantioselectivity of an enzyme has been employed in some industrial processes to upgrade their properties in order to make them more environmentally-friendly. However, large scale industrial implementation of biotechnological reactions is often limited by the marginal stability of the enzyme in the reactor conditions. In our laboratory we employ NMR and circular dichroism to investigate the effect of external crowding agents to improve the activity and stability of several enzymes.
PhD candidates should send a detailed CV including a brief application letter describing their research interest. Candidates must have resided or carried out their main activity (work, studies, etc.) in Spain for less than twelve months in the three years immediately prior to the deadline for applications (estimated: February 2021). The candidate will be asked to submit an application to the “la Caixa” INPhINIT Incoming Fellowship Programme 2021 before Oct. 24.
Tagged as: Life Sciences
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