A post-doctoral position is available at the Schorn lab, Cold Spring Harbor Laboratory, NY. We are interested in how small RNAs identify and silence transposable elements when they become active during mammalian development and disease.
We found that tRNA fragments (tRF) derived from the 3’-end of mature tRNAs are highly expressed in cells undergoing epigenetic reprogramming and target LTR-retroelements, or endogenous retroviruses (ERVs), at their conserved tRNA primer binding site (PBS). Due to the perfect sequence complementarity of 3’-tRFs to the PBS, they have tens of thousands of targets in mammalian genomes. 3’-tRFs are processed under yet unknown conditions and potentially protect many eukaryotes. This is an exciting new field with many opportunities! We believe tRFs are an ancient link between RNAi, transposons and genome stability.
We are determining the intersection of tRFs with other small RNA silencing pathways and their eﬀect on pluripotency and diﬀerentiation. Our main tools are cell culture transposition assays, long & small RNA sequencing, chromatin IPs, NGS analysis of repetitive sequences, CRISPR, etc.
• Schorn AJ, Gutbrod MJ, LeBlanc C, Martienssen R. LTR-Retrotransposon Control by tRNA-Derived Small RNAs. Cell 2017 Jun 29; 170(1):61-71
• Schorn AJ, Martienssen R. Tie-Break: Host and Retrotransposons Play tRNA. Trends in Cell Biology 2018 Oct; 28(10):793-806
• Cullen H, Schorn AJ. Endogenous Retroviruses Walk a Fine Line between Priming and Silencing. Viruses 2020;12(8):E792
• He C, Bozler J, Janssen KA, Wilusz JE, Garcia BA, Schorn AJ & Bonasio R. TET2 chemically modifies tRNAs and regulates tRNA fragment levels. Nature Struct Mol Biol 2021 Jan;28(1):62-70
Please email Dr. Schorn with your interests, CV, and contact information of three references: email@example.com. In addition, candidates should upload their application online at: https://cshl.peopleadmin.com/postings Position ID: 03023-R
Candidates from non-traditional and/or underrepresented backgrounds, broadly defined, are strongly encouraged to apply.
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We offer a competitive salary and comprehensive benefits program, including medical and dental insurance and access to an affordable and licensed on-site childcare center. In addition, CSHLMeetings and Courses program provides an opportunity for interacting with a broad range of researchers and exposure to timely advances in many areas of scientific research.
Founded in 1890, Cold Spring Harbor Laboratory is a world-renowned research and educational institution with programs in cancer, neuroscience, plant biology, genomics, and bioinformatics. CSHL is a private, not-for-profit institution in New York and has been home to eight Nobel Prize winners. Today, CSHL’s multidisciplinary scientific community is bolstered by more than 600 researchers and its Scientific Meetings & Courses Program, which hosts more than 9,000 scientists from around the world each year on its campus. Website: https://www.cshl.edu
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Tagged as: Life Sciences
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