Two fully-funded projects are open to candidates interested in the function of proteins involved in the maintenance of cellular lipid homeostasis in the group of Dr. Alenka Copic, at either PhD or postdoctoral level. We are a young team using interdisciplinary approaches (biochemistry, cell biology, bioinformatics, biophysics). Both projects will be performed in the context of a collaborative network (ERC Synergy Spheres project and ANR MixAndMove project) involving labs in France, Sweden, Italy and Slovenia.
Project I: Regulation of phospholipid distribution in cells
We study the distribution of phosphatidylserine is highly enriched in the cytosolic leaflet of the plasma membrane, where is it essential for controlling cell polarity and signalling reactions. The goal of this project is to study how PS gradient is established in cells by using the model system budding yeast.
Further reading: Moser, Čopič et al. 2015, Science 349:432. doi: 10.1126/science.aab1346; D’Ambrosio et al. 2020, J Cell Sci 133:jcs243733. doi: 10.1242/jcs.243733.
Project II: Function and dysfunction of perilipins on lipid droplets
Lipid droplets play an essential role in cellular metabolism and are present in most cells. In adipocytes, an LD can reach more than 100 µm in size. The goal of this projects is to study how the abundant lipid droplet proteins, the perilipins control the function and size of lipid droplets in adipocytes using cellular and in vitro approaches.
Further reading: Copic et al. 2018, Nat Commun. 9:1332. doi: 10.1038/s41467-018-03717-8; Giménez-Andrés et al. 2021 eLife 10:e61401. doi: 10.7554/eLife.61401.
Team Leader A Copic obtained her PhD from the University of California at Berkeley, followed by postdoctoral training at Columbia University in New York. Having worked as a researcher at the CNRS since 2014, she recently established her independent group at the CRBM. CRBM offers an exciting scientific environment and work at the institute is supported by cutting-edge technical platforms of BioCampus Montpellier (https://www.biocampus.cnrs.fr/index.php/en/). Montpellier is a vibrant city close to the Mediterranean coast, and one of the largest research and education centers in France. Students represent one quarter of the population of Montpellier – one of the highest fractions in Europe. The surrounding area is rich in history, culture, beautiful views and outdoor activities.
To apply, please send your CV, a cover letter and names and contact information of 2-3 references to email@example.com
Tagged as: Life Sciences
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