Dr. Xin Zhou of the Dana-Farber Cancer Institute and Harvard Medical School is looking for 2-3 exceptional Post-doctoral Fellows for her research group (https://zhou-lab.org/). This is an excellent opportunity for postdoctoral candidates interested in protein engineering, antibody discovery, immune engineering, and chemical biology to work on the newest ideas in these fields.
Studies in Dr. Zhou’s lab are aimed at engineering synthetic proteins designed to target immunity both outside and inside of cells, with the ultimate goal of reversing diseases. The immune system, a complex network of cells, antibodies, cytokines, chemicals, and signaling cascades, defends our body against infection, cancer, allergy, and autoimmune diseases. Biomolecular engineering approaches hold the key to the development of novel approaches to not only understand the immune system, but also to precisely control and manipulate it for treating and reversing diseases.
The Zhou lab is driven by a passion for engineering immunity through employing novel biomolecular design and evolution approaches. We engineer novel functional proteins, build switchable antibodies/cytokines, and redesign signaling cascades in immune cells. We combine concepts from chemistry, biophysics, and synthetic biology, to develop next-generation molecular biotechnologies, diagnostics, and therapeutics.
Postdoctoral positions are available in the lab for curious and open-minded scientists to study the following four areas of interest:
1. Evolution and design of novel protein sensors and switches
2. Redesigning signaling pathways in the immune cells (CAR-T, NK cells)
3. Technologies to characterize and targeting the tumor microenvironment
4. Technologies to characterize and targeting the brain
We have state-of-the-art facilities and a highly collaborative, interdisciplinary environment in Dana-Farber’s Longwood Center. We are part of the Chemical Biology program at the Dana-Farber, and our Postdoctoral Fellows are concurrently appointed as Research Fellows in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. We work with amazing partners at Harvard Medical School and other Harvard Medical School-affiliated hospitals. We collaborate with disease-focused scientists and biotherapeutics scientists in both industry and academia to pursue new therapeutic approaches addressing human disease conditions.
As a newly established team, the Zhou lab is keen on cultivating a positive, caring, and inclusive laboratory environment, and focuses our time on training and supporting a new generation of scientists.
A Ph.D. or equivalent doctoral degree in chemistry, bioengineering, biophysics, biology, or related field by the start date is required. Prior experiences in protein design, protein display, immune cell engineering, cell-based screening, or structural biology are a plus but not required.
Candidates are invited to send Dr. Xin Zhou (firstname.lastname@example.org) a CV, contact information of three references, and a cover letter describing past research and future research interests. We also welcome informal inquiries.
Tagged as: Chemistry, Engineering, Life Sciences
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