We are seeking a creative postdoctoral scientist for a Wellcome Trust funded position to study the structural roles and mechanisms of non-coding RNAs in chromatin regulation. The project offers a unique combination of structural biology (cryo-EM), biochemistry and functional approaches in cells.
Enhancer RNAs (eRNAs) are non-protein coding RNAs transcribed from gene-regulatory enhancers. eRNAs play a variety of roles in regulating gene expression, however the structural and molecular basis of these functions is poorly defined. You will study the molecular details of eRNA structure and function, and their interactions with chromatin regulatory enzymes using single-particle cryo-electron microscopy (cryo-EM) together with functional assays. The focus of the project will be cryo-EM, with opportunities to apply cutting edge single-molecule techniques and develop training in mammalian cellular and molecular biology approaches. The project is therefore ideal for scientists looking to expand their expertise in multidisciplinary science.
We are seeking candidates with a PhD (or close to completion/have equivalent experience) in molecular biology or biochemistry. You will have strong expertise and experience in biochemistry, including protein expression and purification or RNA biochemistry. A background in cryo-EM or structural biology (for example, x-ray crystallography, NMR) and protein expression using mammalian cells or baculovirus is desirable but not essential.
You will have excellent communication skills and clearly demonstrate the ability to work effectively as part of a team. You will have the ability to manage your own workload effectively while maintaining the flexibility required for working in scientific environments. You will have the opportunity to make important and regular contributions to the full range of research that our group is engaged in and believe in generating collaborative, considerate and diverse working environments. We are strongly supportive of postdoctoral career development, and you will be encouraged to attend meetings and participate in further training opportunities.
Our lab has been established at The University of Sheffield since 2017. Our research is generously funded by a Sir Henry Dale Fellowship from the Wellcome Trust and Royal Society. We are a welcoming and supportive group, forming part of broader RNA-focused and cryo-EM research communities. We encourage creative thinking and curiosity in our group members and aim to give you space to explore and develop your own ideas about the project. For more information on our research and facilities, please visit our group webpage (www.bose-lab.org), or follow us on Twitter (@bose_lab) or Instagram (@bose_lab). Informal enquiries are welcome and can be made to Dan Bose (firstname.lastname@example.org). Please note, this address is for enquiries only and you should not send your application to this email address.
The Department of Molecular Biology and Biotechnology (MBB) at the University of Sheffield is a broadly oriented department that is internationally recognized for its excellence in biological research using world-class research facilities (https://www.sheffield.ac.uk/biosciences/mbb). We are a close research community, part of a strongly interconnected cross-faculty biosciences program at Sheffield. We have a proud history of Biological research: Professor Hans Krebs discovered the Krebs cycle while in the department, and the University has hosted six Nobel prize winners in science.
The University of Sheffield are one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.
We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to the greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.
To find out what makes the University of Sheffield a remarkable place to work, watch this short film: www.youtube.com/watch?v=7LblLk18zmo, and follow @sheffielduni and @ShefUniJobs on Twitter for more information.
Tagged as: Life Sciences
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