Brain metastases remain challenging complications of solid tumors, and their incidence increases. In malignant melanoma, the majority of patients will develop brain metastases during the course of the disease. First clinical results of checkpoint inhibitors (Ipilimumab, Nivolumab, Pembrolizumab) regarding effectivity against brain metastases look promising, but response durations are often limited, and many patients do not respond at all.
The aim of this project is to understand the dynamics of how T-cells attack melanoma cells in the brain, focussing on the early stages of brain metastases. Most importantly, we aim to investigate the mechanisms underlying T-cell infiltration, how checkpoint inhibition leads to sufficient metastasis control; and, most importantly, how to improve their activity by different co-therapies.
Our group is interested in clinically relevant, but also basic questions in brain tumor research. Our lab in the DKFZ is internationally renowned for the study of brain tumors, with a special focus on brain metastases, and intravital imaging. A broad spectrum of technologies will be used. Primarily, our unique mouse brain metastasis models will be employed, and one focus will be on in vivo two-photon microscopy of growing melanoma metastases and their interaction with T-cells in the brain, as established by our laboratory (Kienast et al., Nature Medicine 2010; Feinauer et al., Blood 2021; Tehranian et al., Neuro-Oncol 2021; Messmer et al. in preperation).
• Master’s degree in biology (immunology, molecular cell biology, cancer biology or similar)
• ‘hands on’ experience with basic laboratory techniques (e.g. cell culture, FACS, light
• Theoretical and/or practical background in immunology is very welcome
• Ideally experience with in vivo experimental models and FELASA B course
• High motivation and organisational talent
• Good team player with good communication skills
• Good knowledge of the English language
• Interesting, versatile workplace
• International, attractive working environment
• Campus with modern state-of-the-art infrastructure
• Access to international research networks
• Flexible working hours
• Comprehensive training and mentoring program through the RTG Graduate School
Please send a Coverletter and a CV to Dr. Matthia Karreman (email@example.com).
Tagged as: Life Sciences
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