E11 Bio is on a mission to make single-cell brain circuit mapping a routine part of every neuroscientist’s toolbox. We are a collaborative and interdisciplinary team of scientists and engineers engaged in a neuroscience moonshot project to develop a radical technology platform for scalable mammalian brain mapping. E11 Bio is a non-profit Convergent Research focused research organization located in Alameda, California, pursuing blue-skies neuroscience research yet operating like a nimble, tight-knit start-up. Read our whitepaper and learn more.
E11 Bio is seeking an experienced and motivated scientist to take a lead role developing the next generation of brain mapping technology. As an early team member at E11, you will have a opportunity to establish and lead the E11 Cellular Barcoding team, where you’ll develop innovative methods for viral tracing of neurons at the scale of mammalian brains. Working closely with the molecular connectomics and data science teams, you’ll design experiments, collect data, and analyze, interpret and present next-generation brain circuit mapping results consistent with our commitment to high impact and open science.
Lead E11’s Cellular Barcoding effort, developing a viral (e.g. AAV) strategy for scalably indexing cellular identity and synaptic connectivity in mammalian brains.
Create and utilize a design-build-test pipeline to design, evaluate and validate protein-based cell barcodes and AAV-based protein barcode expression vectors.
Design and execute manual and high-throughput cell-based and in vivo screens to evaluate and optimize expression patterns of candidate protein barcodes in mouse CNS subcellular compartments (e.g. synapses).
Develop and optimize vectors and delivery methods to support tunable control of AAV labeling density in brain tissue.
Work closely with experimental and computational scientists to collaboratively design experiments, analyze experimental data, and interpret results.
Implement, maintain, and extend new and/or existing cellular barcoding solutions, working and coordinating with external partners where appropriate.
Perform experiments with exceptional levels of competence, reproducibility and documentation following appropriate research practices, including excellent laboratory notebook practices.
Prepare internal reports and manuscripts, and present results at internal or external scientific meetings as appropriate.
Provide high quality and professional supervision, management, and mentorship for junior team members.
Tagged as: Life Sciences
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