As a PhD student you will work on cryo-EM studies of virus-host membrane interactions at the ER-C-3 in the Sachse laboratory at Forschungszentrum Jülich with a particular focus on advanced image data analysis methods. The ongoing COVID-19 pandemic caused by SARS-CoV-2 has major global impact on human society, economy and daily life. The pathogenesis of SARS-CoV-2 infection remains unclear, but most likely results from both a direct cytopathic effect of the virus and a pathogenic inflammation-dominated immune response. To gain knowledge about the virological and immunological drivers of COVID-19 pathogenesis and the parameters of immune protection, we united experts from 7 Helmholtz Centers in 4 Helmholtz Research Fields (Health, Environment, Information and Aeronautics, Space & Transport) and 3 university partners across Germany, to create an internationally visible and interdisciplinary network called CoViPa, in which the successful candidates will be embedded. Your tasks include:
– Work on high-resolution cryo-EM structure determination of in situ cellular samples using correlative light and electron microscopy approaches.
– Use and develop cryo-EM image processing methods to determine the 3D structures of biological macromolecules in cells.
– Employ novel imaging approaches and apply computational methods of pattern recognition, artificial intelligence and deep learning to improve in situ 3D reconstruction, segmentation and molecular map interpretation methods.
Tagged as: Life Sciences
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