We are seeking to recruit a cryo-EM developer to advance the biological research and facility activities at the Ernst-Ruska Centre 3 in the field of Structural Biology at the Forschungszentrum Jülich. The facility has a focus on method development by means of novel hardware as well as focused topical biological research in a user center setting.
Your tasks include:
· Develop new acquisition schemes and workflows based on novel hardware including lowest-temperature studies as well as aberration correction to advance low-dose cryo-EM techniques
· Improve sample handling workflows focusing on single-particle and/or tomography data collection combined with CLEM/FIB-SEM approaches
· Support data acquisition and evaluation for in-house and external users on novel hardware, e.g. iDPC-STEM carrying out structural biology projects, with the following possible focus areas: 3D image processing of single-particle and/or tomography data and/or FIB-SEM operation for the preparation of cryo-FIB lamellae of vitrified cells
· Improving methodology for high-resolution cryo-EM structure determination at the ER-C3 for structural biology
The Ernst Ruska-Centre (ER-C) at the Forschungszentrum Jülich houses some of the world’s most advanced electron microscopes and tools for nanocharacterisation. The scientific research combines current issues in condensed matter physics and cryo-EM on biomacromolecules with the aim of advancing electron microscopy methods. Under one roof, the ER-C has a total of 15 electron microscopes including the PICO FEI Titan with a point resolution of 0.5 Å. The facility has been extended with state-of-the-art cryo-microscopes ThermoFisher Titan Krios, Talos Arctica both equipped with a Bioquantum K3 and Talos 120 as well as FIB-SEM Aquilos 2. The Structural Biology division of the ER-C investigates the structural and molecular mechanism of membrane biology processes and pushes the development of cryo-EM related methodology. The Jülich campus hosts a vibrant electron microscopy, biophysics and structural biology community.
Tagged as: Chemistry, Life Sciences
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