The PhD project is focused on the interplay between the formation of focal adhesions (FA) and the organization of the mitotic spindle apparatus in metastatic breast cancer.
Correct spindle orientation is achieved through signaling pathways that provide a molecular link between the cell cortex and spindle microtubules in an F-actin-dependent manner (Zhu et al., J Cell Biol 2013, 200, 773-787; Kschonsak and Hoffmann, J Cell Sci 131, 2018). Mitotic spindle orientation abnormalities and loss of cell adhesion, have been proposed to facilitate cancer invasion and metastasis, yet the molecular mechanisms underlying these processes are largely unknown. To study the interplay between the two processes we will use ex vivo breast cancer models that show different characteristics in response to their invasion and metastatic properties.
The position is initially available for three years.
Applicants should hold a masters’ degree in biology /life sciences with excellent grades, background in cellular biology and biochemistry and need to have strong laboratory and analytical skills. Please send your CV, copies of certificates, transcript of records from both bachelors and masters studies, your research interests and contact addresses of at least two referees.
Further information about our team at http://www.dkfz.de/en/f045/index.php
Tagged as: Life Sciences
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