We are looking for a postdoctoral fellow to join our lab at the University of Oregon.
The Grimes lab investigates mechanisms of how complex three-dimensional shapes form through embryonic patterning, morphogenesis, and growth. For this, we use genetic, imaging, and sequencing technologies, as well as quantitative phenomic and morphometric analyses, primarily in the zebrafish system. Specifically, we are asking: 1) how can an initially symmetric embryo tell its left from right; 2) how does the embryonic body straighten to generate a precisely linear axis; and 3) how is that linear axis then maintained through growth, preventing the formation of scoliosis-like spinal curves? Addressing these questions allows us to make strides towards deciphering how organismal shape arises, information we then use to understand the origin of human disease and which can be leveraged for strategies in regenerative medicine. We are especially interested in the roles of motile and sensory cilia in patterning and morphogenesis. As such, we investigate how motile cilia generate fluid flows as well as the signaling mechanisms by which cilia respond to fluid flow-derived signals in developmental contexts.
The lab opened in 2019 and has been successful in accruing substantial research funds including an NIH R00 Pathway to Independence award, an R35 Maximizing Investigators’ Research Award, as well as grants from private foundations. All lab trainees have been successful in securing fellowships from the NIH, NSF and HHMI. The Grimes lab is committed to inclusive mentoring of all members. The broader environment at the University of Oregon is exceptional for ambitious postdocs. Our science complex is highly integrated, allowing for cross-disciplinary collaborations; our resources and core facilities are exceptional; and we have a world renowned and interactive community of zebrafish researchers (around 11 labs).
The Postdoctoral Scholar will be responsible for undertaking a research project and technical activities related to projects in the lab. Techniques may include zebrafish genetics and genomics, generation of transgenic and mutant lines, confocal live and fixed imaging, standard molecular biology, single cell RNA sequencing, and protein work. Other responsibilities will include designing and conducting experiments, writing manuscripts and research proposals, delivering research presentations at conferences, and training and mentoring of other lab members. The project is fully funded but we expect the candidate will seek fellowship funding from external sources as well.
Applicants can apply at: https://careers.uoregon.edu/en-us/job/528002/postdoctoral-scholar
Informal inquiries can be addressed to firstname.lastname@example.org
Tagged as: Life Sciences
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