The Lee laboratory and Kranzusch laboratory, located at Harvard Medical School and the Dana-Farber Cancer Institute, are focused on understanding the molecular and structural basis of gene regulation in host-pathogen interactions.
Recently, our labs have discovered specialized roles for RNA elements regulating mRNA translation (Lamper et al Science 2020; Lee et al. Nature 2016) and RNA signals synthesized during host anti-viral defense (Morehouse et al Nature 2020; Eaglesham et al. Nature 2019). We are seeking a highly motivated postdoctoral scholar to join our teams as a joint postdoc to establish a new model of virus replication and make fundamental insights into mRNA translation and innate immunity. The project will provide training in a broad set of techniques, including biochemistry, general RNA and molecular biology methods, and cell-based experiments; and provide the opportunity to learn advanced sequencing and structural biology methods.
Qualifications: We are interested in applicants from diverse research experience backgrounds. Applicants with a Ph.D. in biochemistry or molecular and cell biology or previous experience with virology are particularly encouraged to apply. Candidates should be enthusiastic about collaborative and interdisciplinary research, be motivated to develop as an independent scientist, and demonstrate excellent scientific communication skills.
Environment: Located in Boston, Harvard Medical School offers a world-class research environment along with being part of the vibrant research community of the greater Boston/Cambridge area.
To apply: Qualified candidates should send a cover letter, CV, and contact information for three references jointly to:
Dr. Amy Lee: AmySY_Lee@dfci.harvard.edu
Dr. Philip Kranzusch: firstname.lastname@example.org
Details about the labs can be found at:
Please also see our recent publications:
• Lamper et al., Science 2020 “A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress” (https://science.sciencemag.org/content/370/6518/853)
• Lee et al., Nature 2016 “eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation” (https://www.nature.com/articles/nature18954)
• Morehouse et al., Nature 2020 “STING cyclic dinucleotide sensing originated in bacteria” (https://www.nature.com/articles/s41586-020-2719-5)
• Eaglesham et al., Nature 2019 “Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling” (https://www.nature.com/articles/s41586-019-0928-6)
Tagged as: Life Sciences
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