Postdoctoral position in cancer cell biology Full-time

A postdoctoral position is available in the lab of Dr. Andrew Holland (Johns Hopkins University School of Medicine). The Holland laboratory is studying the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease. Our work utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology. A major focus of the group is to develop animal-based models to study the role of cell division defects in genome instability and tumorigenesis.

For more details of our recent publications and research interests please visit our website at www.hollandlab.com.

The successful applicant must have, or be in the process of completing, a PhD. The ideal candidate will have experience in mouse models, cell biology or biochemistry. We also welcome those with backgrounds in engineering, chemistry, and physics who are interested in applying their expertise to biological systems.  All candidates must be highly motivated and have a strong record of independent research

Applications should be sent to aholland@jhmi.edu and should include a letter detailing the candidate’s motivation for this position, a full curriculum vitae including a list of publications and the names and addresses of three referees.

Recent publications:

·      ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification.

Evans, L.T., Anglen, T.*, Scott, P., Lukasik, K., Loncarek, J., and Holland, A.J. EMBO J 40(4). (2021).

·      Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.

Phan, T., Maryniak, A.L.*, Boatwright, C.A., Lee, J., Atkina, A., Tijhuis, A., Spierings, D.C.J., Bazzi, H., Foijer, F., Jordan, P.W., Stracker, T.H., and Holland, A.J. EMBO J  40(1). (2021).

·      Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

Yeow, Z.Y.*, Lambrus, B.G.*, Marlow, R., Zhan, K.H., Durin, M., Evans, L.T., Scott, P.M., Phan, T., Park, E., Ruiz, L.A., Moralli, D., Knight, E.G., Badder, L.M., Novo, D., Haider, S., Green, C.M., Turr, A.N.J., Lord, C.J., Chapman, J.R.* and Holland, A.J.* Nature 585(7824). (2020). *equal contribution

·      Massive centriole production can occur in the absence of deuterosomes in multiciliated cells.

Mercey, O.*, Levine, M.S.*, LoMastro, G., Rostaing, P., Brotslaw, E., Gomez, V., Kumar, A., Spassky, N., Mitchell, B.J., Meunier, A.* and Holland, A.J.* Nature Cell Biology 21: 1544-52. (2019). *equal contribution

·      WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication.

Park, E., Scott, P.M., Clutario, K.M., Cassidy, K.B., Zhan, K., Gerber and Holland, A.J. Journal of Cell Biology 219(1). (2019).

·      PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole to the microtubule wall.

Moyer, T.C. and Holland, A.J. eLIFE 8: e46054. (2019).

Tagged as: Life Sciences