Open position Intravital Imaging of the Metastasis Cascade
For more information on the job, just click in the “detailled job offer” available on the NANOTUMOR Website (on the right, red button).
The Goetz Lab at INSERM U1109 (Tumor Biomechanics, www.goetzlab.com, CRBS, Strasbourg, FR) is seeking a talented postdoctoral scientist with strong background in Intravital Microscopy and Cancer biology and interest in interdisciplinary research.
Our lab uses advanced imaging techniques coupled to microfluidics and animal models to study tumor metastasis at multiple scales. The lab is actively investigating the contribution of mechanical forces as well as extracellular vesicles in metastasis onset. Our approach permits real-time imaging ranging from single-cell metastatic events to whole body tumor progression. Doing so, we aim at understanding how metastasis occurs in relevant and controlled animal models (Goetz et al., 2011, 2014; Follain et al., 2018; Hyenne et al., 2019; Osmani et al., 2019 Ghoroghi et al., 2021).
Our lab has developed, in collaboration with the EMBL and the DKFZ (Heidelberg) unique imaging technologies that offer nanoscale mapping of cellular and subcellular architecture in their most representative environment, notably intravital Correlative Light and Electron Microscopy (iCLEM) (Follain et al., 2018; Hyenne et al., 2019; Karreman et al., 2014, 2016). We aim to expand the intravital imaging to several organs (liver, mammary tissue, lungs, etc..) using, for example, abdominal or lung windows and in the context of breast cancer.
Our lab has recently relocated into the Center for Biomedical Research of Strasbourg (CRBS), a brand new institute that is equipped with multiple platforms and facilities (mouse and zebrafish husbandry, imaging facility, sequencing platform). We benefit from a proximity and regular collaborations with the IGBMC (Illkirch), EFS (Strasbourg), EMBL/DKFZ (Heidelberg) for both photonic and electron microscopy. In addition, the lab is engaged in collaboration with the team of Paul Timpson (Garvan Institute, Sydney) a world-leader in intravital imaging.
The successful candidate will join an interdisciplinary team made of cell and cancer biologists, molecular biologists and physicist. The candidate will be 1. in charge of setting-up surgery and intravital imaging protocols for several models and study 2. tumor cell deformability during metastasis and participate in 3. setting up intravital imaging protocols of extracellular vesicles. The candidate will develop
his project independently, under the close supervision of Olivier LEFEBVRE (mouse surgery), Vincent HYENNE (Extracellular vesicles) and Jacky GOETZ (Metastasis). The candidate is also expected to present his results in the form of publications and international conference presentations, and to participate to writing of grant applications.
For more information on the job, just click in the detailled job offer available on the NANOTUMOR Website (on the right).
For information on the group’s research, see www.goetzlab.com
All applications must be sent to: Jacky G. Goetz (firstname.lastname@example.org)
Tagged as: Life Sciences
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