A postdoctoral Research Scientist position is open in the “Mechanotransduction: from Cell Surface to Nucleus” team led by Nicolas Borghi at the Institut Jacques Monod (UMR7592 CNRS/Université Paris Cité, Paris, France – www.ijm.fr/en/860/equipes/mecanotransduction.htm) to work on a project that aims at revealing how the cortex of epithelial cells transmit forces across scales and transduce them into biochemical signals. This project fits in the general interest of the team to understand how macromolecular complexes transmit and transduce mechanical cues within and between cells, and how these cues affect cell functions such as cell adhesion, migration, proliferation, and transcriptional activity. To do so the team applies and develops genetically engineered tools, quantitative fluorescence microscopies and micromanipulation approaches to quantitatively control and monitor molecular functions within live cells.
The successful candidate will:
– participate in the design of the project,
– use and develop new methodologies,
– carry out experiments,
– analyze and communicate the results,
– write reviews and research articles.
The candidate will use a wide range of approaches including advanced live-cell imaging (FRET, FLIM, FCS) cell biology (mammalian cell culture, transfection, molecular biology…) and cell and tissue micromanipulation.
The candidate should hold a PhD (at the beginning of the contract) in biology or in soft matter physics with a strong interest in biology. The candidate must be rigorous, have excellent organizational and teamwork skills, have the ability to lead, and be able to express himself / herself in English, written and spoken (the practice of French is not compulsory).
The Institut Jacques Monod (IJM), which is housed in a building of 1800 square meters, located on the new campus of the Paris left bank urban project, is one of the main centers of basic research in biology in Paris, and offers a multidisciplinary research environment. The IJM brings together thirty research groups working on cell and developmental biology, biophysics and genomics. The postdoctoral researcher will benefit from an extremely stimulating scientific environment, and will have access to state-of-the-art core facilities (live-cell imaging, electronic imaging and flow cytometry), located at the IJM.
A 2-year salary with a possibility of extension is funded by the ANR (National Research Agency). Applications should include a CV and a letter of motivation summarizing the scientific interests of the candidate, as well as the contact information of two scientists who could provide recommendations.
Tagged as: Life Sciences
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