For a joint collaborative DFG-funded project in infection immunology we are hiring
1 PhD student (m/f/d)
E13 TV-L 65%
Sepsis is a systemic bacterial infection that causes profound immune dysregulation. The consequences are the development of life-threatening recurrent secondary infections and organ failure. Previous work of the labs has shown that an altered differentiation of conventional dendritic cells (cDCs) in the bone marrow toward a “dysregulated“ phenotype contributes to the enhanced susceptibility to secondary infections during sepsis due to so far unknown mechanisms.
The aim of the project is to decipher the impact of plasmacytoid dendritic cells (pDCs) on the differentiation of cDCs in the bone marrow during polymicrobial sepsis. The project is based on a clinically relevant sepsis model and on material from sepsis patients.
The PhD student will focus on the molecular mechanisms underlying the activation of pDCs and their migration into the bone marrow during sepsis. Techniques used: multicolor-flow FACS, transcriptome profiling with bioinformatic analyses, confocal microscopy, protein biochemistry and various immunological assays.
· Very good Diploma/Master degree in biology or related life sciences
· High degree of motivation & enthusiasm in investigating pathomechanisms of infectious diseases & DCs
· Deep knowledge in cellular & molecular immunology, experience in multicolor FACS, and cell culture
· Experience in preparing murine primary immune cells & bioinformatic analyses (multi-Omics)
· Very good skills in independent working, organization, communication, and teamwork
· Excellent English language skills
We are an international team of highly motivated basic research scientists, graduate and undergraduate students. Our lab is well networked within in the national and international scientific community and within the biomedical research groups of the Heinrich Heine University/University Hospital Düsseldorf.
Connected to the PhD position is a membership in the Interdisciplinary Graduate and Research Academy Düsseldorf (iGRAD), a cross-curricular institution that offers a structured educational program including workshops on key professional qualifications, counselling, and targeted support for the qualification of young researchers within the faculty.
The positions may be filled from 1st November 2021 or later. Interested candidates should send their application including motivation letter, CV, references, and copies of relevant school certificates and all university degrees as one pdf file only to firstname.lastname@example.org.
Only applications that fulfill all the formal requirements will be considered!
The pay grade classification depends on the personal and collective legal requirements. The salary is in accordance with the German public service salary scale. The position is third-party funded for the duration of 36 months. The Heinrich Heine University Düsseldorf is and equal opportunity employer. Female scientists are particularly encouraged to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.
Tagged as: Life Sciences
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