PhD position (Ageing & Disease, DNA Repair & Genome Stability): Embryos, Ageing and DNA repair (m/f/d)
Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) on Gene Regulation, Epigenetics & Genome Stability is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.
Activities and responsibilities:
In the fields of “Ageing & Disease” and “DNA Repair & Genome Stability”, the IPP research group of Prof Christof Niehrs offers the following PhD project:
Ageing is commonly believed to start in adulthood. However, there is increasing evidence that organismic ageing begins already during embryonic development. For example, analyses of Down syndrome shows pronounced acceleration of ageing markers already in fetal stages, similar to adult tissues. This indicates that mechanisms of ageing might be productively studied during embryogenesis.
DNA repair plays a key role in preventing premature organismic ageing. We have recently shown that the DNA glycosylase NEIL1 is essential for early frog (Xenopus) development and in mouse embryonic stem cells (Han et al., 2019). Without NEIL1, frog embryos develop skull and tail malformations, due to p53 induction (see Figure). We found that NEILs protect embryonic cells from damaging oxygen derivatives and prevent accumulation of mitochondrial DNA lesions.
PhD project: Embryos, Ageing and DNA repair
We now plan to study how this phenotype relates to ageing, where accumulation of mitochondrial DNA lesions plays a key role. Candidates will use frog embryos and embryonic stem cells to characterize ageing and senescence in developing tissues. They will screen for novel epigenetic and DNA repair regulators, to understand the molecular network involved in these phenotypes. The successful candidate will have a strong background in Molecular or Developmental Biology to study ageing-related phenotypes in embryos. You will apply techniques including embryo culture, microinjection, RNA in situ hybridisation, confocal microscopy, Next Generation Sequencing and bioinformatics data analysis.
If you are interested in this project, please select Christof Niehrs_Ageing as your group preference in the IPP application platform.
What we offer:
Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!
All you need is:
For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd
The deadline for registration is 26 November 2021. Interviews will take place online 17-19 January 2022.
Starting date: 1 March 2022 – 1 September 2022
Tagged as: Life Sciences
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