PhD position (Ageing & Disease): Intestinal Stem Cell Biology in Homeostasis and Cancer
Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) on Gene Regulation, Epigenetics & Genome Stability is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.
Activities and responsibilities:
In the field of “Aging and Disease”, the IPP research group of Dr Natalia Soshnikova offers the following PhD project:
The adult small intestine has many vital functions, including absorption of nutrients, secretion of hormones and barrier in host defence against microorganisms. These functions of the small intestine depend on the correct specification and maintenance of differentiated cell types within the columnar epithelium. Enterocytes, which process and absorb nutrients, comprise the major cell population of the intestinal epithelium. The next largest group is goblet cells that secret protective mucus. Paneth cells expressing anti-microbial peptides as well as growth factors are part of the stem cell niche. Tuft cells are part of type 2 immunity. Various enteroendocrine cells secreting more than 20 hormones make the small intestine the largest endocrine organ. The intestinal epithelium is exposed to a harsh environment: microorganisms, xenobiotics, and food metabolites. As a result, the epithelial cells need to be rapidly replaced. To maintain tissue homeostasis, intestinal stem cells (ISCs) support continuous renewal of the epithelium.
PhD Project: Functions of endothelial cells during differentiation of intestinal stem cells
Intestinal stem cells and their progenies receive multiple signals from the surrounding non-epithelial cells, such as fibroblasts and immune cells. Yet, it remains unknown how endothelial cells regulate differentiation of the intestinal epithelium. The gut endothelium is a complex paracrine organ. The crosstalk between the gut epithelium and endothelium is essential for the remodelling of the gut microbiota to protect against diet‐induced obesity. Using genetically modified mouse models, organoids, single-cell RNA-sequencing, proteomics, flow cytometry and confocal microscopy you will define signals secreted by the gut endothelium that modulate the differentiation capacity of intestinal stem cells.
What we offer:
Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!
All you need is:
For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd
The deadline for registration is 26 November 2021. Interviews will take place online 17-19 January 2022.
Starting date: 1 March 2022 – 1 September 2022
Tagged as: Life Sciences
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