PhD position (DNA Repair & Genome Stability): Telomere Dynamics in C. elegans (m/f/d)
Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) on Gene Regulation, Epigenetics & Genome Stability is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.
Activities and responsibilities:
In the fields of “DNA Repair & Genome Stability”, the IPP research group of Dr Falk Butter offers the following PhD project:
At the terminus of linear chromosomes, there are unique structures called telomeres that are critical for the stability and integrity of the genome. Telomeres are so integral to cells that we observe their dysregulation in over 90% of cancers (Jafri et al., 2016). Telomeres possess tandem repeats bound by proteins that protect, structure, and serve as an interface for protein recruitment and interaction. In vertebrates, the core complex of telomere-end binders consists of six proteins called shelterin. This complex contains both double- and single-stranded DNA binding proteins bound by bridging proteins to form the chromosome cap (de Lange, 2018). Although highly conserved in functionality, the proteins associated with telomeres have evolved rapidly across different species (Saint-Leandre and Levine, 2020). Using quantative proteomics, we have identified a number of new putative telomere-binding proteins in C. elegans and have now characterized the first double-strand telomere-binding proteins (Dietz et al., 2021). With its diverse impacts on fields ranging from developmental biology to genetics to neurobiology, C. elegans continues to facilitate unique and fascinating insights into telomere biology (Corsi et al., 2015).
PhD project: Characterization of new telomeric proteins in C. elegans
We are looking for a motivated student with interest in telomeres, molecular biology, and C. elegans as a model organism. The first step will be to assist in the follow up characterization of TEBP-1 and TEBP-2 in relation to telomere length regulation. The second portion of this project will be to characterize additional candidates discovered in the initial proteomics screen. Previous experience in either C. elegans or telomere biology is not required, as support will be provided.
If you are interested in this project, please select Falk Butter_Telomeres as your group preference in the IPP application platform.
What we offer:
Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!
All you need is:
For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd
The deadline for registration is 26 November 2021. Interviews will take place online 17-19 January 2022.
Starting date: 1 March 2022 – 1 September 2022
Tagged as: Life Sciences
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