PhD position (Epigenetics & Nuclear Dynamics): Epigenetic readers in plants (m/f/d)
Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) on Gene Regulation, Epigenetics & Genome Stability is offering talented students the chance to work at the cutting edge of research. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.
Activities and responsibilities:
In the fields of “Epigenetics & Nuclear Dynamics”, the IPP research group of Dr Falk Butter offers the following PhD project:
While the stored genetic information in the genome is stable, regulatory mechanisms control when and how this genetic information is used in different contexts. These modification are part of the epigenomic and epitranscriptomic regulatory network and encompass covalent attachment of methylation on DNA, RNA and histones. These marks are recognized by different proteins termed readers that execute their functionality. In our project, funded by the German Ministry of Education and Research (BMBF) within its call for “Epigenetics – Chances for plant research”, we will use quantitative interactomics empowered by mass spectrometry to identify reader proteins in diverse plant species to obtain a systematic picture of epigenetic readers in plants. This work builds on our experience to identify epigenetic readers at different levels in diverse species such as human (Vermeulen et al., 2010), birds (Bluhm et al., 2016), drosophila (Worpenberg et al., 2021) and also in plants (Harris et al., 2018). You will use molecular biology techniques and combine these with state-of-the-art proteomics to identify epigenetic readers for DNA, RNA and histone marks in diverse plant species.
PhD project: Systematic identification of epigenetic reader proteins in plants by quantitative proteomics
We are looking for a motivated student with interest to apply quantitative interactomics techniques to understand epigenetic regulation in plants from a systems perspective. Experience in mass spectrometry or proteomic data analysis is not required at the beginning. However, a firm interest to work with large-scale omics data and readiness to gain bioinformatics skills during the project is requested. Support for advanced computational analysis is provided by a PostDoc bioinformatician co-funded within this project. Furthermore, interest for pursuing collaborational opportunities in the broader biological area is expected.
If you are interested in this project, please select Falk Butter_Plants as your group preference in the IPP application platform.
What we offer:
Are you an ambitious, young scientist looking to push the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!
All you need is:
For more details on the projects offered and how to apply via our online form, please visit https://www.imb.de/phd
The deadline for registration is 26 November 2021. Interviews will take place online 17-19 January 2022.
Starting date: 1 March 2022 – 1 September 2022
Tagged as: Life Sciences
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