The Nayar laboratory at Johns Hopkins University is seeking a postdoctoral research fellow to perform mechanistic and functional genomics studies focused on understanding the mechanisms of therapeutic response and resistance in advanced breast cancer.
The laboratory is based in the Department of Biochemistry and Molecular Biology at the Johns Hopkins University’s Bloomberg School of Public Health, and is also a member of the Department of Oncology/ Cancer Invasion and Metastasis Program/ Women’s Malignancies Disease Group at the Johns Hopkins University School of Medicine. The major goal of the laboratory is to use systematic functional genomics methodologies and high-throughput screens, along with mechanistic cell signaling and mouse models, to better understand the molecular determinants of response and resistance to targeted therapies in the context of metastatic breast cancer (see: PMID: 30531871).
The postdoctoral fellow will have the opportunity to participate in a rich learning environment in the department, which includes multidisciplinary faculty actively engaged in cutting-edge areas of cell, molecular, and structural biology. The Nayar laboratory is a highly collaborative group, engaging both intra-and inter-departmentally across the Schools of Public Health and Medicine. In addition, projects within the lab provide opportunities for building inter-institutional networks through our ongoing collaborations.
Projects include but are not limited to: 1) deep mutational scanning methodologies to enable structure-function studies of oncoproteins relevant to the therapeutic context (see: PMID: 31925410), 2) epigenomics of endocrine resistance, 3) whole-genome screens to understand mechanisms of response and resistance to therapies in breast cancer (see: PMID: 32723837), and 4) investigating the emerging role of inflammatory signaling and the tumor microenvironment in resistance.
In addition, the laboratory works closely with medical oncologists and computational biologists at the School of Medicine to enable rapid translation of laboratory findings to the clinic, to speed the application of personalized or “precision” medicine for patients with advanced refractory breast cancer. For additional details, see nayarlab.org.
Job Qualifications: PhD in cell or molecular biology, or a related field, is required
The ideal candidate should have:
· a background in cancer research and experience with molecular biology, genomic analyses, biochemistry and cell biology
· extensive hands-on research experience and outstanding technical skills
· sound scientific approach to experimental design, data analysis and interpretation
· strong communication and interpersonal skills, and be highly motivated to contribute to understanding resistance in order to impact cancer care.
This is a full time, 40 hour per week position. The initial appointment will be for one-year, renewable annually.
Instructions for applying: Interested candidates please email email@example.com directly with the following:
1) A cover letter summarizing past research experience and accomplishments, and highlighting fit for this position
2) A CV listing all publications
3) A list of three references
Applications will be considered on a rolling basis until the position is filled.
Tagged as: Life Sciences
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