Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes (http://pelechanolab.com/). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.
The available postdoctoral position concerns developing and applying novel approaches to study the crosstalk between gene expression and metabolism at single cell level. The candidate will use those technologies to investigate singe-cell heterogeneity in cancer cell lines and investigate how altered metabolic states shape gene expression. The candidate is expected to contribute his/her own ideas to the common goal of understanding how altered cellular metabolism contributes to the appearance of divergent cellular phenotypes. The candidate will perform original research in genomics, and acquire the required experimental and computational skills necessary for the completion of the project. The candidate will be responsible for integrating different kinds of biological information to answer relevant questions. The successful candidate will take a strong lead in the experimental design, and collaborate with other team members. The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate is also expected to participate in the general duties of the team and to effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.
The candidate will work in a project in collaboration with our colleagues at MDC-BIMSB (Piazza lab: https://www.mdc-berlin.de/piazza ; https://thewittysquare.eu ; https://www.mdc-berlin.de/bimsb). Applicants interested in starting a postdoctoral project at Karolinska Institute for one year and continue his/her training in Berlin are specially encouraged to apply.
Applicants to this position should have a PhD in Molecular Biology, Genetics, or related fields. The successful applicant should also have experience interpreting biological data and experimentally testing their hypothesis. Previous experience in Eukaryotic transcriptional regulation and metabolism will be highly considered. A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential. Preferred experience also includes familiarity with epigenetics, single-cell technologies, tissue culture, immunohistochemistry, bioinformatics, NGS data analysis and molecular biology techniques. Good interpersonal skills and ability to work in teams is essential. Previous experience in proteomics and biochemistry will be meriting. Applicants wishing to integrate experimental and computational biology approaches are also encouraged to apply.
Tagged as: Life Sciences
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