Are you a synthetic chemist, polymer chemist, protein or biochemist? Are you interested in cancer biology and drug design? Then apply to our lab to work on cancer drug design, protein engineering, and cancer proteomics.
We are a group of physicians and scientists in the Molecular Pharmacology Program at the Sloan Kettering Institute and Department of Pediatrics and the Tow Center for Developmental Oncology at the Memorial Sloan Kettering Cancer Center.
We leverage proteomics to develop improved biologic therapies, computational modeling to define oncogenic mechanisms, and innovative mouse models to determine biological functions and guide clinical trials of improved treatments, particularly for children with refractory cancers.
We are developing functional mass spectrometry proteomics methods to define oncogenic signaling, and develop new macromolecular cancer drugs. In particular, we have been using peptide barcoding to construct libraries of cell-penetrant peptidomimetic inhibitors of oncogenic proteins. Recently, we used this approach to successfully develop the first effective inhibitor of MYB, an essential oncoprotein in the majority of blood cancers, as recently published in Nature Communications 2018 and Elife 2021. Current efforts are focused on applying this technology for protein engineering and development of new peptide conjugates for cancer and gene therapy.
An ideal candidate is a PhD graduate with experience in analytical chemistry or protein engineering, who is interested in developing an independent research programme for future faculty or scientist positions in biotechnology and drug design.
We value diversity in ideas and people, and our group seeks excellence and equity in scientific discourse and scientific practice. Memorial Sloan Kettering Cancer Center is a vibrant academic community, part of the Tri-Institutional campus with Rockefeller University and Weill Cornell Medical College, located in the middle of Manhattan in New York City. We offer a unique and unparalleled research environment in cancer biology and oncology with diverse basic and applied science programs, which are directly integrated with clinical care, enabling rapid translation of improved therapies for patients.
Please send a detailed cover letter describing your past research and interests and current CV to Alex Kentsis, MD, PhD at email@example.com.
Tagged as: Chemistry, Engineering, Life Sciences
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