PhD Programme in Biomedical Sciences is a programme at the Doctoral School of Exact and Natural Sciences at the Jagiellonian University in Krakow with a strong inter-disciplinary, international inter-sectoral research and training dimension. The offered position will be located at Malopolska Centre of Biotechnology https://mcb.uj.edu.pl/ (MCB) and will be partly funded by NCN-research grant.
The project will be led by Dr. Neli Kachamakova-Trojanowska within Molecular Mechanisms of Disease Lab (https://mcb.uj.edu.pl/molecular-mechanisms-of-disease-lab).
Patients with maturity onset diabetes of the young (MODY), a disease caused by a mutation in HNF1A gene, often develop vascular complications. To model the disease-specific mechanisms which are responsible for the impairment of the vascular function, patient-derived induced pluripotent stem cells (iPSCs) differentiated toward endothelium, could be a valuable tool. In the current project, the molecular basis of increased permeability of endothelial cells, derived from iPSCs, with mutations in the HNF1A gene will be better understood. We will try to elucidate the role of reactive oxygen species, calcium signalling, mitochondrial function and cell junction proteins in HNF1A-MODY vascular pathology.
What we offer:
· Work within exciting project with cutting-edge techniques in an international environment, with English as our working language;
· Advanced training in scientific techniques and professional skills;
· Access to our state-of-the-art Core Facilities at MCB
· Fully funded positions with financing until the completion of your thesis
If you are motivated to join our team, please send your CV, names and addresses of two professional references and a letter describing your motivation for this project at firstname.lastname@example.org . We would like to receive your application before Monday 7th of June 2021. The interviews will be held between 14-18 June 2021 (online). Start of the position September-October 2021.
The regular recruitment is handled via Jagiellonian University Online Application System. The calls are published and applications are possible two weeks before the deadline (8th of June 2021). Once published, the calls are available through the Online Application System at Doctoral Schools>Doctoral School of Exact and Natural Sciences>Biomedical Sciences (Malopolska Centre of Biotechnology). One applies to the common doctoral programme indicating the research topics of interest. Matching of successful applicants and the topics of interest (Principal Investigators) is done after completion of the recruitment procedure (https://science.phd.uj.edu.pl/en_GB/programy/mcb-jcet-nauki-biomedyczne-nauki-biologiczne- ).
All additional information about the vacancy can be obtained from Dr. Neli Kachamakova-Trojanowska (email@example.com ).
Tagged as: Life Sciences