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Postdoctoral Fellow
Post-doc positions – Single-molecule, Super-resolution, and In situ Structural Biology Approaches Full-time
The Pertsinidis lab in the Structural Biology Program of the Sloan Kettering Institute at MSKCC has immediate openings for postdoctoral associates.
A major focus in our lab is developing cutting-edge single-molecule detection and super-resolution optical imaging techniques. We further apply the tools we develop to visualize and understand some of the most fundamental biological processes that power cellular life. For example, our lab has developed modulation interferometry, a single-molecule localization-based super-resolution technique with ~1-2 nm 3D precision and target-locking 3D nanoscopy, a technique that achieved single-molecule detection in high background, crowded intracellular environments. These tools have enabled some of the highest resolution single-molecule studies to date, providing new biological insights that could not be obtained before (e.g. Wang et al. Cell 2016; Li et al., Cell 2019).
Successful applicants will become an important member of our vibrant, interdisciplinary team of physical and biological scientists. We now develop the next-generation of low-background, non-invasive and photon-efficient techniques – to further enhance our ability to visualize biological processes in live cells with single-molecule sensitivity, (sub)-millisecond temporal and (sub)-nanometer 3D spatial resolution. We also further push the limits of extracting high-resolution information from weak signals in optically inhomogeneous, thick, multi-cellular environments, such as tissue explants, 3D organoids and the developing embryo. Finally, we develop new single-molecule imaging and machine learning technologies – to enable in situ high-resolution structural biology inside cells.
Requirements:
· Desire to tackle outstanding challenges in optics, microscopy and/or single-molecule biology
· Ph.D. degree in Physics, Chemistry, Optics, Optical Engineering, Biophysics or a relevant scientific or engineering field.
· Ability to work effectively in a collaborative, multidisciplinary environment.
Experience with single-molecule detection instrumentation and high/super-resolution optical imaging (e.g. STED/RESOLFT, 4Pi, MINFLUX, SIM, LLS/SPIM approaches, Adaptive Optics, etc.) is preferred but not required. Individuals with additional working knowledge in areas of biochemistry, molecular, cell and developmental biology and/or genetics are strongly encouraged to apply. Please send a CV, names and contact information of three references, and a short description of scientific interests to Dr. Alexandros Pertsinidis (PertsinA@mskcc.org).