The Ruvkun Laboratory (https://www.ruvkun.hms.harvard.edu/) in the Department of Molecular Biology at Massachusetts General Hospital (MGH) is seeking a motivated Senior Research Associate to join our research group. The Ruvkun lab pursues C. elegans molecular genetics projects in the fields of small RNAs and viral immunity, and mitochondrial, ribosomal, and proteasomal surveillance. A PhD is required. The salary range for Senior Research Associates is $70K to $85K, depending on experience. Course work or experience in genetics, phylogenetic comparison, and functional genomics are helpful. Experience in other genetic systems such as yeast genetics, bacterial genetics, Drosophila genetics, or C. elegans genetics very helpful. We are also interested in people who have studied the genetics of diverse bacteria or intensive genetic analysis of more standard bacteria such as E. coli or B. subtilis. Many projects also involve bioinformatics, so experience in computational biology valuable. The Ruvkun lab is best known for its work on small RNAs and regulation of C. elegans lifespan. But over the past two decades, we have discovered that a variety of ancient cellular pathways are surveilled for disruption by microbial toxins to trigger immune responses that include production of antiviral siRNAs. The engine of the lab is now full genome sequencing of newly generated mutations in large-scale genetic screening. Because our genetics constantly sends the lab into new fields, diverse fields are explored in the lab. There are currently 11 members of the lab. The Department of Molecular Biology at Massachusetts General Hospital is a dozen faculty members. We recruit from diverse training institutions and in this era of racial reconciliation we have redoubled our efforts in this.
The candidate for the Senior Research Associate will become proficient in biochemical techniques, designing, and executing experiments, analyzing, and visualizing data, recording experimental details and results in an electronic notebook, and presenting summaries of work or scientific papers in lab meeting and journal club.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
Conduct genetic screens for mutants defective in RNA interference and related processes.
Lead the interpretation of data and results.
Regularly communicate project status updates via team meetings.
Coordinate and interact closely with other scientists on data quality and file management.
Actively participate in the preparation of manuscripts for publication and present at scientific conferences.
Assist in peer- and student-mentorship, shares expertise, provides training and guidance as needed.
Participate within a team of scientists to foster a culture of scientific excellence and collaboration.
Sound understanding of statistics and biological concepts coupled with data science skills to collect, clean, analyze and visualize complex biological data.
Strong analytical skills and the ability to function and communicate effectively in a highly productive multi-disciplinary environment.
Track record of leading – or playing an important role – in prior scientific publications.
Genomic analysis tool familiarity helpful.
Excellent communication, organization, and time management skills.
Possess effective communication skills such as empathetic reflecting, active listening, clear instruction, and engaging presentation skills.
Minimum Required: Doctoral Degree
Field of Study/Additional Specialized Training:
Ph.D. in Genetics, molecular biology, or biochemistry, or other relevant scientific discipline or equivalent experience required
At least two years of experience working with genetics in any system from bacteria to humans.
Recognized excellence as evidenced from preprints or peer-reviewed publications
Genetic analysis expertise and molecular biology expertise
Ph.D. in Molecular Biology, Genetics, Cell Biology, or other relevant scientific discipline or equivalent experience required
At least two years of experience working with molecular genetics.
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives, and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Research at the Department of Molecular Biology (MOLBIO)
Established in 1982, MOLBIO’s mission is to advance knowledge and to improve human health. Operating at the frontiers of fundamental and translational molecular biology, MOLBIO provides an environment that allows scientists to push the limits of knowledge. It offers premier training conditions for early-career researchers, to launch careers in academia, industry, and government. Members of the Department carry out basic genetic and molecular biological research on a variety of topics. At present, approximately 170 people, including 13 faculty and over 85 postdoctoral fellows and graduate students comprise the Department of Molecular Biology. The Department is a major component of the Department of Genetics at Harvard Medical School. All Molecular Biology faculty, postdoctoral fellows and graduate students have concurrent appointments at Harvard, mostly in HMS Genetics. Research at MOLBIO includes organelle biogenesis, chromatin biology, brain signaling, 3D genome organization, mitochondrial biology and disease, neuroscience, innate and adaptive immunity, micro-RNA and small RNA pathways, and biophysical mechanisms of developmental disorders. Massachusetts General Hospital has a long-standing relationship with Harvard Medical School. Mass General is consistently ranked among the top hospitals in the United States. The hospital is part of a larger integrated healthcare and research system in Massachusetts called Mass General Brigham, consisting of Brigham and Women’s Hospital and other affiliates and members.
The Department of Molecular Biology at Massachusetts General Hospital is a part of both the research community of the hospital and the Division of Medical Sciences of the Harvard Graduate School of Arts and Sciences. Members of the Department carry out basic genetic and molecular biological research on a variety of topics at the cutting edge of the discipline. The Department is a major component of the Department of Genetics at Harvard Medical School. All Molecular Biology faculty, postdoctoral fellows and graduate students have concurrent appointments at Harvard, mostly in HMS Genetics. Massachusetts General Hospital has a long-standing relationship with Harvard Medical School. Massachusetts General Hospital was established to provide care to Boston’s sick, regardless of socioeconomic status, and became the first teaching hospital of Harvard University’s medical school. We have remained at the forefront of medicine and biomedical research by fostering a culture of collaboration and education, pushing the boundaries of scientific research. Please visit http://molbio.mgh.harvard.edu/ to meet our faculty and learn more about our department.
We seek new department members in all capacities who have the interest and drive to continuously enhance our workplace culture. Because of our diversity we excel, through inclusion we respect our community, and with a keen focus on equity we serve, heal, educate, and innovate at the highest levels. When you become a member of the Department of Molecular Biology, you join undergraduate students, graduate students, post-doctoral fellows, facilities and research support staff, administrative staff, technicians, and faculty from around the world that are invested in creating a welcoming, collaborative, and innovative scientific environment.
Location & Accessibility
The Molecular Biology Department, located at 185 Cambridge Street in Boston, Massachusetts in the Simches Research Building, remains ideally located for commuters off the red line. Many employees use the public transportation (MBTA) system to reach work. Parking options may also available.
Tagged as: Life Sciences
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