An exciting opportunity has been created for an experienced researcher to join Dr. Theodore Braun’s laboratory as a senior research assistant at Oregon Health & Science University’s Knight Cancer Institute in Portland, OR. The primary goal of the Braun Laboratory is to understand how changes in the epigenome influence the development of blood cancers. We employ a variety of high sensitivity and single cell methods to understand how early oncogenic mutations alter the epigenetic landscape of developing blood cells driving progression to cancer. We conduct this work using cell lines, mouse models and primary patient samples, enabling us to develop a comprehensive mechanistic understanding of biologic mechanisms.
This position is funded by a collaborative grant from the Alliance for Early Cancer Detection with researchers from the University of Cambridge to study the biology of clonal hematopoiesis (CH), a pre-leukemic condition which occurs in up to 20% of the aging population. The goal of this work is to identify new treatment approaches for individuals with high-risk CH that might serve as the basis for a preventative strategy. These studies will include high-throughput drug screening; in vitro validation of candidate drugs in cell lines with CH mutations and in vivo validation in CH mouse models. As many CH mutations act via alterations in the epigenome, single cell and high sensitivity epigenetic studies will also be performed. Additional duties will include molecular biology and biochemistry research techniques, flow cytometry, NGS library preparation, mammalian tissue culture, small animal handling, data analysis, and other laboratory techniques. We are particularly interested in candidates who are adept with molecular genomic techniques. Applicants will need to possess strong organizational and communication skills as well as the ability to work independently.
Bachelor’s degree and laboratory experience in molecular/cellular biology, biochemistry, chemistry, cancer biology or a related field is preferred. Salary will be commensurate with experience. We are looking for an enthusiastic individual who is capable and willing to make maximum use of excellent facilities and a productive environment. Some weekend work is required.
Tagged as: Life Sciences
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