Postdoctoral Fellow
Neuroimmunology Postdoctoral Associate Full-time
We seek a Neuroimmunology Postdoctoral Associate to join the recently established Laboratory of Chemical Immunology and Proteomics at the Rockefeller University. You will have an opportunity to work directly with the Head of the Laboratory establishing both the organization and culture of the Laboratory and will have extensive opportunities to gain new skills through interactions with colleagues and collaborators in other labs. This is an exciting opportunity for a candidate who is interested in working in an interdisciplinary environment, contributing with their neurobiology or neuroimmunology skillset, while gaining expertise in proteomics methods and chemical biology.
Laboratory Description
The laboratory of Chemical Immunology and Proteomics applies synthetic chemistry, chemical biology, and proteomics methods toward the goals of discovering and characterizing (a) novel selective chemical probes that perturb the functions of key proteins regulating immunological and neuroimmunological processes; (b) new mechanisms for small molecule-induced protein degradation; and, more broadly, (c) the pharmacological landscape and signal transduction pathways in immune and neuroimmunological disorders. Achieving these objectives is enhanced through the development of new chemical scaffolds targeting cysteine and other nucleophilic residues. By developing and applying innovative chemical proteomic profiling technologies, we aim to enrich our understanding of the molecular differences between pathologic and physiologic states in immune cells and cells of the nervous system (including microglia and oligodendrocytes, which are implicated in the autoimmune disorder multiple sclerosis). The lab also plans to explore how those differences can be further leveraged from a pharmacological perspective for the development of new therapies that not only target specific immune cell subtypes, but also the defined activation states of these cells. Please see www.vinogradovalab.com for more information.
Job Requirements/Qualifications
• Thorough working knowledge of neuroimmunology or neurobiology;
• Experience performing mouse brain dissections, work with glial cells, as well as some of the following cell and molecular biology techniques are required: mammalian cell culture, PCR, RT-PCR, cloning, viral transduction, CRISPR-Cas9 gene editing, protein expression, immunoprecipitation, SDS-PAGE, and Western-blot;
• Experience with biochemical assay development is a plus;
• The candidate should be scientifically motivated, detail-oriented, capable of independently conceiving, conducting and critically analyzing their own research;
• Consistent track record of academic accomplishments (e.g., peer-reviewed publications and/or patents);
• Effective written and oral communication skills;
• PhD degree in Neuroscience, Cell biology, Chemical Biology, Molecular biology, Biochemistry, Immunology, Pharmacology or a related field of biology is required.
How to Apply
We offer a competitive salary, comprehensive benefits, and a collaborative work environment.
Please e-mail your CV and a cover letter to Prof. Ekaterina (Katya) Vinogradova (vinograd@rockefeller.edu) and arrange for 3 reference letters to be sent directly to Prof. Vinogradova.
The Rockefeller University is an Equal Opportunity Employer – Minorities/Women/Disabled/Veterans