Do you want to be part of a small group working to understand the development of the immune system and immune responses to diverse conditions like radiation sickness, cancer, and infectious disease?
Are you interested in how some of the most abundant but overlooked signaling molecules are also some of the most powerful immune regulators?
Then we are looking for you!
The Blaho Lab participates in two programs at SBP: the Immunity and Pathogenesis Program in the Infectious and Inflammatory Diseases Center and the Aging, Cancer, and Immuno-oncology Program in the NCI-designated Cancer Center. Our goal is to understand how the immune system is shaped by a family of bioactive lipids, the lysophospholipids, particularly sphingosine 1-phosphate (S1P). We are interested in all aspects of S1P signaling, including the S1P GPCRs, the chaperone molecules that carry S1P (ApoM-HDL and albumin), and the metabolism of S1P itself. We explore these pathways using a combination of animal models, in vitro systems, pharmacology, biochemical analyses, and single cell technologies. The specific project can be discussed, but there are currently two wide-ranging topics: 1) How S1P affects the response to radiation and genotoxic stress, especially by bone marrow stem/progenitor cells and the endothelium, and 2) How ApoM-S1P and S1P receptor signaling impacts the generation of immunity. Models include experimental autoimmune encephalomyelitis (EAE) and ionizing radiation, as well as genetic models of receptor and chaperone deletion and over-expression.
Those applying for a Postdoctoral Associate position should have a Ph.D., M.D., or M.D., Ph.D. in biological sciences, pathology, biochemistry, or similar subject and have the ability to successfully spearhead a research project, as evidenced by a first author peer-reviewed paper (published or accepted). You should be experienced in tissue culture, standard molecular biology techniques (e.g., PCR, western blotting, protein quantification, etc.), and also have working experience with respectful and skilled mouse handling or be eager to learn. Successful candidates will have the rare opportunity of being a foundational member of a new and growing team with access to state-of-the-art technologies, one-on-one mentorship, and the highly collaborative and energetic environment of SBP and the Torrey Pines Mesa. The position is fully funded by the NIH, but Postdoctoral Associates will be expected to work with Dr. Blaho to identify potential projects and funding organizations to target for fellowship opportunities, including our NIH T32 program: Frontiers in Immunology.
For consideration, please email Victoria Blaho (firstname.lastname@example.org) to tell her about your interests and include your CV and a copy of one of your publications. Our group is dedicated to increasing diversity and striving for equity in the lab and beyond, so we encourage applications from individuals that are part of an under-represented minority community.
Knowledge, Skills, Experience
Tagged as: Life Sciences
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