Scientist II (Downstream) Full-time

Scientist II, Downstream

Sanofi Manufacturing and Supply Organization is preparing its future through an ambitious program named Modulus. The Modulus Project is at the cornerstone of Sanofi's strategy, aiming to create a new generation of flexible, multi-product manufacturing facilities that are modular, adaptable, and powered by digital and automation technologies. The Singapore site is one of the flagship greenfield facilities designed to support both vaccine and specialty care biologics production, serving patients globally.

Manufacturing Sciences, Analytics and Technology (MSAT) plays a critical role in bridging R&D and manufacturing. It drives process industrialization, continuous improvement, and lifecycle management of biologics products while integrating innovative technologies and data-driven approaches.

The MSAT team is seeking a Scientist II, Downstream, who will be responsible for independently designing and executing laboratory studies to support manufacturing troubleshooting, technology transfer, and lifecycle management of biologics processes. This role works closely with MSAT process engineers to translate manufacturing challenges into scientific experiments and deliver data-driven insights to support production operations.

Duties & Responsibilities

Laboratory studies & scientific execution

• Design and execute small- to mid-scale downstream laboratory studies to support manufacturing investigations, process improvements, and technology transfer
• Collaborate with MSAT engineers to define study objectives and develop robust experimental protocols
• Author study plans, protocols, reports, and technical documentation in compliance with GLP requirements
• Analyze and interpret experimental data, and present findings to cross-functional stakeholders
• Ensure laboratory activities are conducted safely, efficiently, and within timelines

Manufacturing support & troubleshooting

• Provide downstream process expertise to support manufacturing investigations and root cause analysis
• Design and execute lab studies to support CAPA development
• Work closely with MSAT engineers and lab leadership on process-related challenges
• Support flexible working hours or urgent activities when required

Laboratory operations

• Maintain laboratory readiness, including equipment setup, maintenance, and troubleshooting
• Manage inventory of consumables and coordinate with vendors and suppliers
• Ensure compliance with GLP, HSE, and documentation standards
• Maintain accurate laboratory records and approve operational documentation

Technology transfer support

• Support scale-down model development, bridging studies, and technology transfer activities
• Contribute to preparation of technical documentation for process transfers
• Drive standardization and knowledge-sharing practices within the site and Sanofi network

Lifecycle management & continuous improvement

• Analyze trends from manufacturing and laboratory data to identify improvement opportunities
• Support downstream process optimization and continuous improvement initiatives
• Contribute to change management activities, including risk assessments and documentation
• Stay updated with industry trends and emerging downstream technologies

Mentorship & team development

• Mentor trainees and interns in laboratory techniques and downstream processing concepts
• Contribute to a collaborative and high-performance laboratory culture

Pre-requisites

Knowledge, Skills & Competencies

• Strong analytical and problem-solving skills with a data-driven mindset
• Effective communicator in cross-functional and multicultural environments
• Ability to work independently with a high level of scientific autonomy
• Scientifically curious with strong diagnostic and consultative capabilities
• Proficiency in DOE (Design of Experiments) and statistical analysis tools
• Familiarity with PAT (Process Analytical Technology) tools is advantageous

Qualifications

• Advanced degree (MSc/PhD preferred) in Biotechnology, Biological Sciences, Chemical Engineering, Chemistry, or related fields
• Hands-on experience in biopharmaceutical laboratory environments, specifically in downstream processing
• Strong expertise in:
  • Chromatography (e.g., affinity, ion exchange, SEC)
  • Filtration techniques (TFF/NFF)
  • Viral inactivation and clearance processes
  • Relevant analytical techniques
• Experience in designing, executing, and reporting laboratory studies independently
• Strong understanding of downstream process interactions and critical parameters
• Experience with scale-down models and/or technology transfer is highly desirable
• Familiarity with GLP, HSE, and basic cGMP requirements