About our organisation
We are one of the world’s most influential cancer research institutes with an outstanding record of achievement dating back more than 100 years. We are world leaders in identifying cancer genes, discovering cancer drugs and developing precision radiotherapy. Together with our hospital partner The Royal Marsden, we are rated in the top four centres for cancer research and treatment worldwide.
As well as being a world-class institute, we are a college of the University of London. We came top in the league table of university research quality compiled from the Research Excellence Framework (REF 2014).
We have charitable status and rely on support from partner organisations, charities, donors and the general public. We have more than 1000 staff and postgraduate students across three
sites – in Chelsea and Sutton.
About the Tumour functional Heterogeneity Team
Cancers emerge as a result of somatic evolution often leading to genetic and phenotypic heterogeneity that culminates in metastatic dissemination of therapy-resistant, lethal tumoural clones. The characterization of such diversity is crucial to our understanding of the
dynamics that govern the cancer ecosystem.
The Tumour Functional Heterogeneity (TFH) team, led by Dr Marco Bezzi, combines preclinical modelling, functional genomics approaches and multi-parameter single-cell analysis to investigate tumour heterogeneity. Two major research areas of the lab are i) identification of cancer trajectories of convergent evolution in response to therapy and ii) mechanisms of co-operation between cancer clones within their microenvironmental context. Ultimately, the TFH lab aims to design innovative therapeutic approaches that exploit cancer vulnerabilities and anticipate drug resistance.
The TFH lab is part of Centre for Evolution and Cancer and of the Division of Molecular Pathology. It is located at the newly built, multidisciplinary Centre for Cancer Drug Discovery in Sutton, London.
About the position
We are looking for an enthusiastic postdoctoral research fellow to deliver
a CRUK funded research program that will shed light on how intra-tumoural phenotypic diversity affects clonal dynamics and their interaction with the tumour microenvironment.
The successful candidate will collaborate with other members of the lab to generate high-dimensional datasets (CyTOF, CODEX and scRNA-seq) using organoids and in vivo models of prostate cancer. The post-holder will be leading on the bioinformatics analysis under the
supervision of the team leader and the co-supervision of Prof Andrea Sottoriva, leader of the Evolutionary Genomics and Modelling team.
The ideal candidate holds a PhD/DPhil (or near completion) in bioinformatics or computational biology with a strong background in cancer biology and an undergraduate degree in molecular biology or a similar subject. Significant wet-lab experience in sample preparation for high-parameter cell suspension profiling, multiplexed spatial tissue imaging and single-cell RNA sequencing would be an advantage. Demonstrable R programming skills and experience of analysis of CyTOF data are essentials.
Informal enquires are welcome and can be
made to Dr Marco Bezzi (email@example.com).
Tagged as: Life Sciences
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