The Oudin Lab in the Department of Biomedical Engineering at Tufts University is seeking a postdoctoral associate interested in cancer biology to join our growing research team. We are a collaborative, international, inclusive and supportive team of individuals trying to understand mechanisms of cancer metastasis and how these may impact response to therapy in the context of breast cancer. Please checkout our website: www.madeleineoudinlab.com or on Twitter @MadeleineOudin.
We are looking for post-doctoral researchers interested in studying the neuronal identity of solid tumors in the context of a newly-funded DP2 New Innovator Grant. We are focused on studying the role of nerves in the tumor microenvironment. Perineural invasion has been associated with tumor aggressiveness by providing a path for cancer cell invasion, however, for a long time, these nerves were not seen as major drivers of tumor growth and metastasis. We have also found that tumor cells take on neuronal properties, such as the genes they express and their bioelectrical properties.
We are interested in : 1- elucidating the mechanisms by which neoneurogenesis of solid tumors occurs, via soluble, cell-cell contact, electrical or metabolic cues, which will lead us to evaluate the systemic effects of nerves on local invasion and metastasis 2- dissecting the neuronal identity of epithelial tumors, by studying how neuronal mimicry in metastasizing cells contributes to tumor progression. We use a range of in vitro approaches to study tumor cell adhesion and invasion using live microscopy and xenograft and genetic mouse models. We believe these projects have the potential to impact both our basic understanding of the role of the TME in tumor metastasis as well as lead to the development of novel detection and treatment approaches for metastatic disease.
Candidates should have a PhD in biology or biomedical engineering, with experience in cell culture, molecular biology, signaling, neuroscience. Experience with in vivo models is not necessary. As a member of the Oudin lab, you would receive extensive mentorship from Dr. Oudin and others in the community, and would be given opportunities to mentor undergrad researchers, apply for fellowships and participate in teaching. As part of the outstanding scientific community in the Boston area, we have collaborations with several institutions and hospitals, with many more opportunities for interactions with local biotech.
Interested applicants should email Dr. Madeleine Oudin (email@example.com) and send 1- a cover letter describing their background, research interests, and career goals; 2- a complete CV; and 3- the name and contact information for three references.
Tagged as: Engineering, Life Sciences
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