Ph.D position in the Pharmacology field at University of Lleida/IRBLLeida
ABOUT THE PROJECT:
Drug repurposing is a fast and inexpensive strategy to reuse already approved drugs. This is especially useful in the context of diseases with limited therapeutic approaches. Actually, this therapeutic gap is present in the pharmacological management of Crohns disease (CD). CD is a chronic inflammatory condition that can affect any part of the intestinal tract. The intestinal inflammation is mediated by cytokine such as TNF-α, which plays a pivotal role in the intestinal destruction of these patients. Anti-TNF-α biologic drugs have become the gold standard for the pharmacological management of CD. However, owing to the characteristics of these drugs, 20 to 40% of patients are or become resistant to it. Therefore, it is mandatory to find alternative drugs that circumvent these limitations. Genome-wide association studies have uncovered several links between CD and autophagy. In this sense, research conducted in autophagy-deficient animals has shown an increased susceptibility of the intestinal epithelial cells to TNF-α-driven cell death.
The project will use a high-throughput screening to identify compounds exerting a cytoprotective effect against TNF-α-mediated cell death. The most suitable
candidate(s) will undergo a thorough characterization of their mechanism of action in the context of TNF-α-driven cell death. This work will be the a first-step in repositioning the selected candidate(s) for the pharmacological management of CD.
Candidates must have obtained a University Degree and a Masters Degree in Biomedical sciences within the European Higher Education System (minimum 300 ECTS) or an equivalent University Degree that allows to start a PhD.
Candidates must have an excellent academic record of 8 or more (Spanish grading system, see link below), previous research experience and a strong commitment for scientific research.
How to apply:
Applications must be submitted online to firstname.lastname@example.org.
Academic transcripts must be included.
Tagged as: Life Sciences
Opening position to candidates for 2 PhD positions associated to a project from the Spanish Ministry of Science and Innovation...Apply