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Postdoctoral Fellow
Esophageal Adenocarcinoma Genomics Postdoctoral Fellowship Full-time
The Latner Thoracic Surgery Laboratories at the University Health Network in Toronto is inviting applications for a Post-Doctoral Fellow. The successful candidate will lead a project defining genomic and transcriptomic features in esophageal adenocarcinoma. Our samples include laser capture microdissected whole genome and RNA-seq samples from pre-treatment primary tumour biopsies, post-treatment surgical resections, and metastatic biopsies. Moreover, a subset of patients have samples from more than one specimen type. We have sequenced ~40 whole genomes and 50 whole transcriptomes with a goal to reach 100 samples. The candidate will be part of an integrative group including members from a comprehensive clinical program in esophageal cancer, experts in esophageal adenocarcinoma patient derived organoid models, cancer biologists, and bioinformaticians. The successful candidate will be supervised by a clinician-scientist PI and a bioinformatics/genomics PI.
• Design and perform computational analyses with the principal investigators
• Keep appropriate records, code, and documentation
• Contribute to the development of Whole Genome and Transcriptome analysis pipelines on a high-performance computational cluster
• Analyzes, interprets, and summarizes sequencing data
• Develop novel and deploy existing methods/algorithms to analyze tumour evolution / cancer subclones in the context of somatic mutations, structural variants, and copy number changes.
• Assist in the preparation of publications, conference abstracts and grant proposals
The candidate should have demonstrated experience in cancer biology and basic coding experience. Previous experience analyzing cancer whole genome sequencing data is an asset. Candidates must have a Ph.D. or M.D. in a similar field and work well in team environments with great interpersonal skills and excellent written and verbal communication.