Dr. Enfu Hui’s lab at UC San Diego and Dr. Wenxian Fu’s lab at Genentech is recruiting a joint postdoctoral fellow to work on the molecular mechanisms of the immune checkpoint pathways with exciting clinical relevance. The selected candidate will be supported by a postdoctoral fellowship from Genentech and receive a multidisciplinary training in biochemistry, cell biology, cellular imaging and cancer immunology from two well-established PIs with complementary expertise.
The UC San Diego is located on the La Jolla Mesa in close proximity to The Scripps Research Institute, the Salk Institute, and the Sanford Burnham Prebys Medical Discovery Institute Research and provides a highly stimulating, collaborative, and interactive research environment in a beautiful location.
Considered as the founder of biotech industry and now a member of the Roche Group, Genentech is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.
Related recent publications from the Hui lab:
Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors.
Xu X*, Masubuchi T*, Cai Q, Zhao Y, Hui E. Elife. 2021;10. Epub 2021/11/05. doi: 10.7554/eLife.74276. PMID: 34734802.
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
Xu X*., Hou B*., Fulzele A., Masubuchi T., Zhao Y., Wu Z., Hu Y., Jiang Y., Ma Y., Wang H., Bennett E., Fu G., Hui E. Journal of Cell Biology, 2020
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Zhao Y, Lee CK, Lin CH, Gassen RB, Xu X, Huang Z, Xiao C, Bonorino C, Lu LF, Bui JD, Hui E. Immunity. 2019 Nov 15. PMID: 31757674.
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells.
Zhao, Y., Harrison, D. L., Song, Y., Ji, J., Huang, J., and Hui, E. Cell Rep 2018;24:379-90 e376.
Related recent publications from the Fu lab:
TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.
Yang BH, Wang K, Wan S, Liang Y, Yuan X, Dong Y, Cho S, Xu W, Jepsen K, Feng GS, Lu LF, Xue HH, Fu W. Cell Rep. 2019 Jun 18 PMID: 31216480
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity.
Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. Cell Metab. 2019 Feb 5 PMID: 30595478
CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms.
Yuan X, Dong Y, Tsurushita N, Tso JY, Fu W. JCI Insight. 2018 Jan 25 PMID: 29367461
CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells.
Yuan X, Yang BH, Dong Y, Yamamura A, Fu W. Elife. 2017 Nov 24 PMID: 29171836
Additional information can be found at
We welcome highly motivated and collaborative candidates who have
1. a PhD in cellular immunology, biochemistry, molecular biology or cell biology.
2. a track record of successfully completed research project(s), first-author publication(s) in impactful journals.
3. creative problem-solving skills and excellent oral/written communication skills.
Candidates with mechanistic thinking and microscopy experience are preferred. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or disability.
How to Apply:
To apply, please email both Dr. Enfu Hui (click Apply button for email) and email@example.com
Email applications should include:
Cover letter summarizing previous research experience and future goals
CV with complete publication list
Contact information for 3 referees
Tagged as: Life Sciences
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