We are looking for candidates with a recent Ph.D. to fill two open postdoctoral positions. The ideal candidates should have a strong background in cell biology, molecular biology and biochemistry applied to signal transduction research with a translational flavor. Preference will be given to candidates with strong productive track record and experience.
Our Accomplishments: Our lab strives to study the cell biology of signal transduction, with a focus on heterotrimeric G-proteins (trimeric-GTPases). These classes of G proteins have been found on a variety of intracellular membranes since the early 1990’s; what they do there remained a mystery. We have systematically pursued in-depth the biological implications of this intracellular trimeric-GTPase system; it is modulated by a novel family of guanine-nucleotide exchange modulators (GEMs) and is fundamentally distinct from the conventional trimeric-GTPase signaling from the cell surface by G protein-coupled receptors (GPCRs). Although modulation of trimeric-GTPases by GPCRs remains a core target of modern medicine, our discoveries have revealed that trimeric-GTPase signaling via GEMs is just as important, if not more, for coordinating cellular responses in physiology and for diagnosing and alleviating human suffering.
Examples of projects/areas of current interests available for postdoc fellows:
1) Macrophage polarization and the innate immune response: Implications in autoimmune disorders.
2) G proteins in injury, inflammation and repair: Implications in liver fibrosis.
3) Regulation of planar cell polarity, and implications during development and in cancer: Implications in cancer initiation and progression.
4) Structural basis for the action of GEMs, and their potential as drug-gable targets: Structure guided drug discovery.
5) Structure-based identification of novel GEMs in the human genome.
6) Other projects studying the role of GEMs and the G proteins in cellular processes: a) polarized exocytosis; b) DNA damage repair; c) mitochondrial dynamics; d) cell-cell junctions and epithelial barrier function.
Tagged as: Life Sciences
The Overholtzer lab in the Cell Biology Program at the Memorial Sloan Kettering Cancer Center in New York, NY has...Apply
The lab of Dr. Janna Fierst in the Department of Biological Sciences at Florida International University (FIU) is searching for...Apply
Postdoctoral Fellow, Genome Editing Technology Development – Kleinstiver Lab.We are seeking postdoc candidates to join this multifaceted team seeking to...Apply
A postdoctoral position is available in the Kerlin Research Laboratory within the Center for Clinical and Translational Research of the...Apply
Several NIH funded postdoctoral/staff positions are available to study the biology of neurodegeneration. The broad goals of this project are...Apply
Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with...Apply