Postdoctoral fellow positions are available in the laboratory of Professor Yuan Chen at UC San Diego. The laboratory has a long history in developing approaches to target ubiquitin-like modifications and elucidating the roles of ubiquitin-like modifications as cancer therapeutic targets. We have funding to support several post-doctoral positions. Examples of potential projects in chemical and structural biology area include the development of approaches to address novel targets or minimize side effects of current approaches. Additional examples of available projects include anti-tumor immune response pathways, such as regulation of tissue-specific Treg cell development by ubiquitin-like modifications, macrophage mediated tumor cell killing by small ubiquitin-like modifications, and translational studies in pancreatic, colorectal, and head and neck cancers, as well as addressing proteasome inhibitor resistance of multiple myeloma.
Professor Chen’s laboratory takes multi-disciplinary approaches. The positions offer great opportunities for participating in one of the training programs in Cancer Biology and Therapeutic Development, and collaborating with leading laboratories in the vibrant biomedical research community of UC San Diego, the nearby partnership institutions and biotech companies.
Examples of recent publications:
Du L, Fakih M, Rosen S, Chen Y. SUMOylation of E2F1 regulates expression of EZH2. Cancer Research, in press.
Li YJ, Du L, Wang J, Vega R, Lee TD, Miao Y, Aldana-Masangkay G, Samuels ER, Li B, Ouyang SX, Colayco SA, Bobkova EV, Divlianska DB, Sergienko E, Chung TDY, Fakih M, Chen Y. Covalent Inhibition of Ubiquitin-like Modifications by a Novel Class of Inhibitor of SUMO Activating Enzyme. Cell Chemical Biology, 26(2):278-288, 2019.
(Featured: Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme. Magin RS, Doherty LM, Buhrlage SJ. Cell Chemical Biol. 26(2):153-155, 2019).
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, Chen Y, Sun Z. Sumoylation of RORγt regulates TH17 differentiation and thymocyte development. Nature Communications. 9(1):4870, 2018.
Lv Z, Yuan L, Atkison JH, Williams KM, Vega R, Sessions EH, Divlianska DB, Chen Y, & Olsen SK. Structure of SUMO E1/allosteric inhibitor complex reveals a novel strategy for targeting ubiquitin and ubiquitin-like modifier signaling. Nature Communications, 9(1):5145, 2018.
Barry R, John SW, Tenev T, Chen C-H, Choi J, Kasperkiewicz P, Alnemri E, Drag M, Chen Y and Meier P. SUMO-mediated Regulation of NLRP3 Critically Modulates Inflammasome Activity. Nature Communications, 9(1):3001, 2018.
Li Y-J, Du L, Aldana-Masangkay GI, Wang X, Urak R, Forman S, Rosen ST, and Chen Y. SUMOylation Regulates miR-34b/c Targeted Gene Expression Program. Nucleic Acid Research, 46(14):7108-7123, 2018.
Qualifications Required/Academic Background
The candidates should have demonstrated productivity by having made important contribution to the field. They should also be dedicated and creative problem solver and team player.
Salary, commensurate with previous accomplishments and experience.
Please submit research interests, Curriculum Vita and names of three references.
Job Type: Full-time
Pay: $51,000.00 – $71,000.00 per year
Hospital & Health Care
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Tagged as: Chemistry, Life Sciences
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