The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application.
Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future. For further information, go to: https://www.cruk.cam.ac.uk/jobs-and-studentships/postgraduate-study
Dr Pau Creixell wishes to appoint a student to work on the project entitled: A new arm in cancer signaling: Uncovering twin phosphotyrosine signaling and its role in cancer.
For further information about the research group, including their most recent publications, please visit their website: https://www.cruk.cam.ac.uk/research-groups/creixell-group
Our newly established lab combines machine learning approaches with high-throughput biochemistry to study how proteins recognise their substrates, how cancer could perturb this process, and how to find highly selective drugs to overcome drug resistance in cancers.
To understand their role in healthy and cancer cells, it is essential to identify the specific substrates that a kinase phosphorylates. Protein tyrosine kinases select their specific target sites from a large collection of tyrosine sites. This specificity is largely achieved through recognition of a consensus motif; the amino acid sequence that surrounds the phospho-acceptor site and fits into the active site of the kinase in a key-lock principle.
Our unpublished data suggests that a large number of pro-oncogenic tyrosine kinases use previously phosphorylated tyrosine sites adjacent to the phospho-acceptor tyrosine to recognize their substrates (twin phosphotyrosine signaling). Using an in vivo mouse model of leukemia, we have shown that this new signaling arm of twin phosphotyrosine sites downstream of many oncogenic kinases may paradoxically function to suppress tumor progression. In this project, we will develop new reagents to be able to selectively identify twin tyrosine sites and further characterize twin tyrosine signaling and its role in cancer.
Miller, C. et al. Trends Biochem Sci 43, 380¿394 (2018).
Begley, M. et al. Nat Struct Mol Biol 22, 983¿990 (2015).
Creixell, P. et al. Cell 163, 187¿201 (2015).
Creixell, P. et al. Cell 163, 202¿217 (2015).
As a recently established lab, we are particularly interested in students who will be highly motivated and share our excitement for science. You should be independent while also capable of taking feedback and input from others. While we will consider candidates from all backgrounds, those with interests in biology, chemistry, physics and/or machine learning/artificial intelligence may have an advantage.
This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum.
No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.
How to apply:
All applications need to be made using the University Applicant Portal. Please visit: https://www.graduate.study.cam.ac.uk/courses/directory/cvcrpdmsc for further information about the course and to access the applicant portal.
To complete your on-line application, you need to provide the following:
Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.
Research: If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the ‘Research summary’ text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the ‘Research Supervisor’ text box. Please describe your past ‘Research experience’ in the appropriate text box.
Course Specific Questions: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.
Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results
The closing date for applications is 15 November 2020, with interviews expected to take place in December/January.
Please quote reference SW24216 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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