The Martin lab in the Department of Fundamental Microbiology at the University of Lausanne offers two postdoctoral positions in the field of cell communication and polarization.
How does a cell orient in response to a chemical cue ? This basic problem is at the core of how cells interact with their environment for behaviors as diverse as feeding, identifying an invader or finding a mate for sexual reproduction. Our lab uses one of the simplest eukaryotic models, the fission yeast S. pombe, to understand fundamental principles of gradient sensing. We previously showed that these cells use a speed-dating process to find a mate for sexual reproduction, where dynamic polarity patches secrete pheromones and become stabilized in response to those produced by the other mating type. We are launching an ERC-funded research program to understand gradient decoding at the molecular level, and how mechanisms may be modulated in natural variants.
The research program uses simple fission yeast cells to tackle an old and universal problem in cell biology : how do cells orient in a chemical gradient ?
You will develop a research project within this program aimed at addressing one of the following questions :
– What are the rules governing how cells find a mate during sexual reproduction ?
– What are the molecular mechanisms coordinating pheromone sensing and cell polarization ?
– How does genetic diversity in natural yeast populations modify these rules and mechanisms ?
Research projects will use a mix of approaches including quantitative imaging, optogenetics, molecular genetics and genomics.
– PhD thesis (or planned defense at time of application)
– Good publication record
– Curious and open mind with high motivation to excel in science
– Strong interest in cell and molecular biology
We are looking for candidates with a strong background in quantitative imaging, but also for candidates with expertise in genomics interested in applying them to answer cell biological questions. Prior expertise in yeast genetics not essential.
Tagged as: Life Sciences
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