The Stephens Lab (https://www.bio.umass.edu/biology/stephens/home) at the University of Massachusetts Amherst is recruiting a Postdoctoral Research Associate. The Stephens lab studies the mechanical and shape properties of the cell nucleus and how these properties affect major nuclear functions such as genome organization, DNA damage, compartmentalization, and transcription. Abnormal nuclear shape has been used as diagnostic and prognostic marker for human disease such as cancer for nearly a century without understanding nuclear mechanical changes that underlie these abnormal deformations. Furthermore, we aim to study the consequences of both change in nuclear mechanics and morphology on nuclear and cell function.
The Postdoctoral Research Associate will be responsible for one of the main aims from our two grants. NIH R00 and UM1. The Postdoctoral Research Associate will be able to choose one or a mix of aims including: 1) Determine the role of higher order chromatin organization and histone modifications in nuclear mechanics and chromatin deformations via our unique micromanipulation force measurement technique of single isolated nuclei. 2) Determine the mechanical basis and altered functionality of chromatin in nuclear blebbing. 3) Determine how nuclear and cell mechanics relate during differentiation and homeostasis loss. The main approaches are biophysical measurements using our unique micromanipulation force measurements and more cell biology focused approaches. The Postdoctoral Research Associate will use these tools to perform experiments on cells using micromanipulation and microscopy to discern the mechanical role of chromatin in the nucleus and how it affects major nuclear functions.
Please apply here: https://careers.umass.edu/amherst/en-us/job/507897/post-doctoral-research-associate-stephens-lab . You will be asked to submit a cover letter, resume, research interests in cell nuclear and morphology and mechanics (1-2 pages), and contact information for three professional references. Apply by June 1, 2021 in order to ensure priority consideration. Search will remain open through the summer to August 31, 2021 until a suitable candidate pool has been identified.
Informal inquiries are also welcome using contact information on our lab website.
Tagged as: Engineering, Life Sciences, Physics
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