Two ITN Marie Curie PhD positions available within the H2020-MSCA-ITN project “GLYTUNES” (www.glytunes.eu), recruitment between Sept. and Nov. 2021
ESR1: Full characterization of bacterial sialylated envelope components
ESR12: Physico-chemical analysis of Siglecs-Glycan complexes
More info here www.glytunes.eu
RECRUITMENT The ESRs will be contractually employed for 36 months by the recruiting organisation and will be covered under the related national social security scheme. ESRs will receive a Monthly Living Allowance plus a Mobility Allowance (where applicable)
ITN Eligibility Rules At the time of recruitment applicants must fulfil the following rules: Experience: – Applicants must be in possession of the degree (usually the Master Degree) which would formally entitle them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited. In case the degree has not been obtained yet, it is necessary to send a declaration of the university stating that the degree will be obtained before the expected starting date – Applicants must be in the first 4 years of their research careers (full-time equivalent research experience) at the signature of the contract (measured from the time the Master’s degree has been obtained). – Eligible applicants must not hold a Doctoral degree already.
Mobility: The applicants must not have resided in the country where the research training activities will take place for more than 12 months in the 3 years immediately prior to the recruitment date, and must not have carried out their main activity (work, studies, etc.) in that country. Exceptions International Organisations: Eligible researchers must not have spent more than 12 months in the 3 years immediately prior to the date of selection in the same appointing international organisation.
Full characterization of bacterial sialylated envelope components (ESR1)
Subject Area Structural and chemical biology; Glycomics and Glycosciences Aims: Science: The project aims to assess the structure and function of cell envelope components isolated from bacterial sialylated envelope glycans. ii) determine conformation and 3D structure of isolated microbial glycans; Training: Expertise in glycomics, microbial glycans structural and chemical biology, organic chemistry, carbohydrate chemistry and biochemistry, analytical chemistry, isolation, purification and characterization of microbial glycans (LPS, EPS, CPS….), NMR spectroscopy and MS spectrometry, computational methods for building 3D complex carbohydrate structures; stage(s) in the industry Expected Results: Formation of the ESR with a solid knowledge in glycomics, glycosciences, structural biology of glycoconjugates. Definition of the structure to function relationships of bacterial cell envelope compounds. Establishment of the molecular mimicry of host glycans from different microbial strains. Stage in the industry; PhD thesis Project-specific selection criteria: good skills in glycomics and glycosciences, carbohydrate chemistry and biochemistry, organic chemistry, glycans structure and biology; good knowledge of techniques for glycans structural biology, as isolation, purification methodologies, NMR spectroscopic, biophysical, spectrometric techniques; microbial glycomics.
Physico-chemical analysis of Siglecs-Glycan complexes (ESR12)
Subject Area Structural and chemical biology; Glycomics and Glycosciences Aims: Science: Study of molecular recognition events in the Siglecs-sialoglycan interaction, comprehension of the binding properties and specificity of Siglecs receptors upon sialoglycans binding; analysis of sialoglycans and proteins region involved in the recognition and binding evente description of the and analysis of the binding regions by NMR spectroscopy, computational approaches and biophysical approaches. Analysis of 3D structures of Siglecs in complex with microbial sialoglycans; Training: in structural biology, NMR spectroscopy to define protein-ligand complexes, biophysical and computational techniques and their applications, with extensive impact in both pharmaceutical industry and academia environments applied to the structural characterization of the complexes of antimicrobials with bacterial envelope targets Expected Results: Learning how the conformation and presentation of epitopes is achieved by using NMR and other biophysical techniques; Learning how this presentation regulates the molecular recognition issues. The integrated approach based on NMR, docking and molecular modeling will profile the ligands’ epitope in their bound conformations and to provide consistent 3D-models of the interaction. With microbial ligands identification of key molecular actors of interactions between microbial ligands and Siglecs. Project-specific selection criteria: good skills/experience in glycomics and glycosciences, glycans structure and conformation; structural biology (NMR spectroscopy); spectroscopic, biophysical, computational, spectrometric techniques for the characterization of 3D complexes, carbohydrate biochemistry, study of protein-ligand interaction via NMR spectroscopy, molecular modelling and biophysical techniques
Tagged as: Chemistry, Life Sciences
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