Funding is immediately available for multiple postdoctoral fellows to study taste receptor signaling in innate immunity, specifically how G-protein coupled taste receptors activate antimicrobial responses in human immune cells and human airway epithelial cells. Our lab uses a combination of live-cell and confocal imaging, biochemistry, and molecular biology approaches using primary human cells isolated from nasal surgical samples and cultured at air-liquid interface. A main focus of our lab is bitter taste receptors, which are expressed in many tissues beyond just the tongue, where they serve largely unknown roles. In the airway, bitter taste receptors detect bacterial products and activate calcium-driven innate immune responses. In macrophages, bitter taste receptors regulate phagocytosis through calcium and NO signaling.
Our lab is located within the Division of Rhinology in the Department or Otorhinolaryngology. More about our lab’s research, equipment and resources, and recent publications by students and postdocs, etc., can be found at www.robleelab.com
The postdocs will work closely with the PI and other lab members in a supportive, enthusiastic, and professional environment that emphasizes collaboration. The postdocs will receive training in live-cell imaging and other techniques as needed, potentially including measurements of calcium, nitric oxide, pH, mitochondrial function, and/or imaging of fluorescent protein biosensors for calcium, cAMP or other signaling pathways. The postdocs will also be expected to independently or collaboratively develop or learn new techniques as required by the project.
Opportunities for professional development (grant writing, review writing, collaborations, conferences, etc.) will be encouraged and supported. Salary and benefit information (based on NIH NRSA stipend levels) and information about postdoctoral policies at Penn are outlined on the Biomedical Postdoctoral Programs website: https://www.med.upenn.edu/postdoc
A PhD in a biological science (cell biology, molecular biology, immunology, physiology, etc.), with demonstration of successful completion of thesis project is required. Experience in cell culture, biochemistry, and/or imaging is highly desirable, but not required. We strive to create a collaborative and supportive environment where training will be provided on core techniques. Communication skills (reading, writing, speaking), enthusiasm, respectfulness of other lab members, and good interpersonal skills are essential. We encourage individuals from underrepresented racial and ethnic groups, and individuals from socially, culturally, economically, or educationally disadvantaged backgrounds to apply. We recognize that scientific research is strengthened by a diverse workforce that brings different backgrounds, perspectives, ideas, and insights to the table to enhance productivity and innovation.
Email the Rob Lee with questions or to apply: rjl [at] pennmedicine.upenn.edu
Tagged as: Life Sciences
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