Postdoc position available:
BIOCHEMICAL MECHANISMS OF HEDGEHOG AND WNT SIGNALING
A postdoc position is available in our group to study signal transduction mechanisms in the Hedgehog and Wnt pathways. These pathways control the development of nearly every organ in our bodies, and, when misregulated, lead to widespread birth defects and cancers. Surprisingly, we still know very little about the biochemical steps underlying Hedgehog or Wnt signaling. We are tackling these longstanding questions by merging membrane protein biochemistry and biophysics in vitro with cell biology and embryology in living cells and organisms.
Our recent studies have provided foundational insights into the activation and downstream coupling mechanisms for SMOOTHENED (SMO), a class F GPCR in the Hedgehog pathway and a major oncology drug target (Deshpande et al, Nature 2021; Arveseth et al, PLOS Biol 2021; Happ et al, biorxiv 2021). These insights have revealed new principles for how lipids can bind and activate GPCRs, and how GPCRs can control intracellular kinases. Our work is also leading to new ways to therapeutically modulate class F GPCR signaling in cancer and other diseases. There are lots of exciting follow-up studies to pursue as postdoc projects in all of these areas!
Projects in our lab would be ideal for a graduating Ph.D. in biochemistry, biophysics, or cell biology. Experience with GPCRs (or other membrane receptors), lipids, in vitro reconstitution, or live-cell imaging is desirable but not necessary. This is a great opportunity for trainees looking to explore the interface between biochemistry, developmental biology, and cancer.
The University of Utah offers a cutting-edge, collaborative scientific environment in a beautiful and affordable metropolis with world-class outdoor activities.
Our work is funded by R35 and R03 grants from the NIH.
Candidates should send a cover letter, CV, and list of 3 references to Ben Myers at email@example.com.
Tagged as: Life Sciences
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