The successful applicant will use biochemical, molecular, cellular biological and genetic approaches to characterize novel types of race-specific disease resistance proteins in wheat. We have recently identified two new types of proteins acting in a race-specific resistance way against leaf rust and powdery mildew, respectively: A membrane-bound ankyrin-repeat protein encoded by the Lr14a gene (see Nature Communications https://doi.org/10.1038/s41467-020-20777-x) and a chimeric kinase-MCTP protein encoded by Pm4 (see Nature Plants https://doi.org/10.1038/s41477-021-00869-2). The applicant will play a key role in the further biochemical and molecular characterization of these novel type of resistance proteins to gain a mechanistic functional understanding. The envisaged project involves the identification of interaction partners from the host and the pathogen, as well as protein functional studies in homologous and heterologous systems. For recent publications in the group also see: scholar.google.com/ (Beat Keller).
Requirements and requested skills:
− Proven experience (including publications in international well-recognized journals) in in-vitro/in-vivo protein biochemistry and molecular biology, ideally in the field of plant-microbe interactions.
− Experience in fluorescence microscopy will be advantageous.
− Ability to frame questions and to test them experimentally.
− Writing skills for scientific publications.
− Excellent English communication skills and the ability to both work in a team and individually.
Starting date: Ideally, early Summer of 2021 (position is open immediately), but given the current situation we are flexible. The position is available for 2-3 years. The successful candidate will be involved in some teaching activities (1 week/year).
− Send a single PDF titled Resistanceposition_familyname to email@example.com, with CV including publication list, a short (max. 2 pages) motivation letter explaining your interest in, and qualification for the position and contact details of 2-3 referees.
− Applications will be reviewed from April 20, 2021 until the position is filled.
The Department of Plant and Microbial Biology provides an excellent in-house infrastructure as well as access to the Central Microscopy and Genomics/Proteomics facilities (https://fgcz.ch/). We offer an international, English-speaking work environment. Zürich is located centrally in Europe and offers easy access to outdoor activities, particularly in the Swiss Alps.
The position is funded by a grant from the Swiss National Science Foundation and in-house funding.
Questions on this position can be addressed to Dr. Javier Sánchez-Martín (firstname.lastname@example.org) and Prof. Dr. Beat Keller (email@example.com).
Tagged as: Life Sciences
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